UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 284,931 Value ($000) $7,736 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 284,828 Value ($000) $5,358 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 178,253 Value ($000) $1,957 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 132,173 Value ($000) $809 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 135,323 Value ($000) $2,225 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	284,931	$7,736	$24.89	$18.05 - $33.00
Q3 2025	284,828	$5,358	$15.54	$10.54 - $21.03
Q2 2025	178,253	$1,957	$9.24	$5.14 - $12.10
Q1 2025	132,173	$809	$9.55	$6.12 - $18.95
Q4 2024	135,323	$2,225	$22.33	$14.97 - $29.46