UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

MORGAN STANLEY's Holding History (CIK: 0000895421)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 122,068 Value ($000) $3,314 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 87,535 Value ($000) $1,647 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 99,308 Value ($000) $1,090 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 51,391 Value ($000) $315 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 43,163 Value ($000) $710 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	122,068	$3,314	$24.89	$18.05 - $33.00
Q3 2025	87,535	$1,647	$15.54	$10.54 - $21.03
Q2 2025	99,308	$1,090	$9.24	$5.14 - $12.10
Q1 2025	51,391	$315	$9.55	$6.12 - $18.95
Q4 2024	43,163	$710	$22.33	$14.97 - $29.46