UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

WELLINGTON MANAGEMENT GROUP LLP's Holding History (CIK: 0000902219)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 894,733 Value ($000) $24,292 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 1,125,395 Value ($000) $21,169 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 1,225,295 Value ($000) $13,454 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 1,313,457 Value ($000) $8,026 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 1,583,154 Value ($000) $25,632 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	894,733	$24,292	$24.89	$18.05 - $33.00
Q3 2025	1,125,395	$21,169	$15.54	$10.54 - $21.03
Q2 2025	1,225,295	$13,454	$9.24	$5.14 - $12.10
Q1 2025	1,313,457	$8,026	$9.55	$6.12 - $18.95
Q4 2024	1,583,154	$25,632	$22.33	$14.97 - $29.46