UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Invesco Ltd.'s Holding History (CIK: 0000914208)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 163,186 Value ($000) $4,431 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 17,190 Value ($000) $323 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 16,300 Value ($000) $179 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 15,315 Value ($000) $94 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 15,602 Value ($000) $256 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	163,186	$4,431	$24.89	$18.05 - $33.00
Q3 2025	17,190	$323	$15.54	$10.54 - $21.03
Q2 2025	16,300	$179	$9.24	$5.14 - $12.10
Q1 2025	15,315	$94	$9.55	$6.12 - $18.95
Q4 2024	15,602	$256	$22.33	$14.97 - $29.46