UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 10,147 Value ($000) $275 Avg Close $24.89 Range $18.05 - $33.00
Q3 2025
Shares 12,092 Value ($000) $227 Avg Close $15.54 Range $10.54 - $21.03
Q2 2025
Shares 13,190 Value ($000) $145 Avg Close $9.24 Range $5.14 - $12.10