UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

DEUTSCHE BANK AG\'s Holding History (CIK: 0000948046)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 127,815 Value ($000) $3,470 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 26,737 Value ($000) $503 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 23,403 Value ($000) $257 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 15,192 Value ($000) $93 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 14,851 Value ($000) $244 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	127,815	$3,470	$24.89	$18.05 - $33.00
Q3 2025	26,737	$503	$15.54	$10.54 - $21.03
Q2 2025	23,403	$257	$9.24	$5.14 - $12.10
Q1 2025	15,192	$93	$9.55	$6.12 - $18.95
Q4 2024	14,851	$244	$22.33	$14.97 - $29.46