UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 27,091 Value ($000) $736 Avg Close $24.89 Range $18.05 - $33.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	27,091	$736	$24.89	$18.05 - $33.00