UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

ALLIANCEBERNSTEIN L.P.'s Holding History (CIK: 0001109448)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 31,010 Value ($000) $842 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 19,850 Value ($000) $373 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 24,560 Value ($000) $270 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 1,091,186 Value ($000) $6,678 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 1,111,337 Value ($000) $18,270 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	31,010	$842	$24.89	$18.05 - $33.00
Q3 2025	19,850	$373	$15.54	$10.54 - $21.03
Q2 2025	24,560	$270	$9.24	$5.14 - $12.10
Q1 2025	1,091,186	$6,678	$9.55	$6.12 - $18.95
Q4 2024	1,111,337	$18,270	$22.33	$14.97 - $29.46