UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 10,500 Value ($000) $285 Avg Close $24.89 Range $18.05 - $33.00
Q3 2025
Shares 10,500 Value ($000) $198 Avg Close $15.54 Range $10.54 - $21.03
Q1 2025
Shares 21,789 Value ($000) $133 Avg Close $9.55 Range $6.12 - $18.95