UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 517,264 Value ($000) $14,044 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 40,113 Value ($000) $755 Avg Close $15.54 Range $10.54 - $21.03

Q1 2025

Shares 61,796 Value ($000) $378 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	517,264	$14,044	$24.89	$18.05 - $33.00
Q3 2025	40,113	$755	$15.54	$10.54 - $21.03
Q1 2025	61,796	$378	$9.55	$6.12 - $18.95