UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,527,958 Value ($000) $41,423 Avg Close $24.89 Range $18.05 - $33.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,527,958	$41,423	$24.89	$18.05 - $33.00