UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Altshuler Shaham Ltd's Holding History (CIK: 0001324290)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,341,540 Value ($000) $36,423 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 1,416,822 Value ($000) $26,650 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 3,394,441 Value ($000) $37,271 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 3,235,293 Value ($000) $3,520 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,341,540	$36,423	$24.89	$18.05 - $33.00
Q3 2025	1,416,822	$26,650	$15.54	$10.54 - $21.03
Q2 2025	3,394,441	$37,271	$9.24	$5.14 - $12.10
Q1 2025	3,235,293	$3,520	$9.55	$6.12 - $18.95