UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Mariner, LLC's Holding History (CIK: 0001373442)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,830 Value ($000) $321 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 10,933 Value ($000) $206 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,830	$321	$24.89	$18.05 - $33.00
Q3 2025	10,933	$206	$15.54	$10.54 - $21.03