UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

NORGES BANK's Holding History (CIK: 0001374170)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,882,647 Value ($000) $78,264 Avg Close $24.89 Range $18.05 - $33.00

Q2 2025

Shares 969,916 Value ($000) $10,650 Avg Close $9.24 Range $5.14 - $12.10

Q4 2024

Shares 1,000,000 Value ($000) $16,440 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,882,647	$78,264	$24.89	$18.05 - $33.00
Q2 2025	969,916	$10,650	$9.24	$5.14 - $12.10
Q4 2024	1,000,000	$16,440	$22.33	$14.97 - $29.46