UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

PRELUDE CAPITAL MANAGEMENT, LLC's Holding History (CIK: 0001387508)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,560 Value ($000) $450 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 15,735 Value ($000) $296 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,560	$450	$24.89	$18.05 - $33.00
Q3 2025	15,735	$296	$15.54	$10.54 - $21.03