UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Bank of New York Mellon Corp's Holding History (CIK: 0001390777)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 84,853 Value ($000) $2,304 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 91,521 Value ($000) $1,722 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 79,766 Value ($000) $876 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 36,912 Value ($000) $226 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 36,913 Value ($000) $607 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	84,853	$2,304	$24.89	$18.05 - $33.00
Q3 2025	91,521	$1,722	$15.54	$10.54 - $21.03
Q2 2025	79,766	$876	$9.24	$5.14 - $12.10
Q1 2025	36,912	$226	$9.55	$6.12 - $18.95
Q4 2024	36,913	$607	$22.33	$14.97 - $29.46