UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

CITADEL ADVISORS LLC's Holding History (CIK: 0001423053)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 13,420 Value ($000) $364 Avg Close $24.89 Range $18.05 - $33.00

Q4 2024

Shares 180,000 Value ($000) $2,959 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	13,420	$364	$24.89	$18.05 - $33.00
Q4 2024	180,000	$2,959	$22.33	$14.97 - $29.46