UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

SUSQUEHANNA INTERNATIONAL GROUP, LLP's Holding History (CIK: 0001446194)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 55,841 Value ($000) $1,516 Avg Close $24.89 Range $18.05 - $33.00

Q2 2025

Shares 42,263 Value ($000) $464 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 21,264 Value ($000) $130 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	55,841	$1,516	$24.89	$18.05 - $33.00
Q2 2025	42,263	$464	$9.24	$5.14 - $12.10
Q1 2025	21,264	$130	$9.55	$6.12 - $18.95