UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Nantahala Capital Management, LLC's Holding History (CIK: 0001472322)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 494,971 Value ($000) $13,438 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 594,971 Value ($000) $11,191 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 594,971 Value ($000) $6,533 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 594,971 Value ($000) $3,641 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 600,000 Value ($000) $9,864 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	494,971	$13,438	$24.89	$18.05 - $33.00
Q3 2025	594,971	$11,191	$15.54	$10.54 - $21.03
Q2 2025	594,971	$6,533	$9.24	$5.14 - $12.10
Q1 2025	594,971	$3,641	$9.55	$6.12 - $18.95
Q4 2024	600,000	$9,864	$22.33	$14.97 - $29.46