UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

MetLife Investment Management, LLC's Holding History (CIK: 0001529735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 19,678 Value ($000) $534 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 21,691 Value ($000) $408 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 21,691 Value ($000) $238 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 11,034 Value ($000) $68 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 11,034 Value ($000) $181 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	19,678	$534	$24.89	$18.05 - $33.00
Q3 2025	21,691	$408	$15.54	$10.54 - $21.03
Q2 2025	21,691	$238	$9.24	$5.14 - $12.10
Q1 2025	11,034	$68	$9.55	$6.12 - $18.95
Q4 2024	11,034	$181	$22.33	$14.97 - $29.46