UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Tower Research Capital LLC (TRC)'s Holding History (CIK: 0001533421)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 669 Value ($000) $18 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 1,868 Value ($000) $35 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 3,051 Value ($000) $34 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 1,582 Value ($000) $10 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 2,846 Value ($000) $47 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	669	$18	$24.89	$18.05 - $33.00
Q3 2025	1,868	$35	$15.54	$10.54 - $21.03
Q2 2025	3,051	$34	$9.24	$5.14 - $12.10
Q1 2025	1,582	$10	$9.55	$6.12 - $18.95
Q4 2024	2,846	$47	$22.33	$14.97 - $29.46