UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 26,600 Value ($000) $722 Avg Close $24.89 Range $18.05 - $33.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	26,600	$722	$24.89	$18.05 - $33.00