UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

UBS Group AG's Holding History (CIK: 0001610520)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,806,243 Value ($000) $49,039 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 272,271 Value ($000) $5,121 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 232,887 Value ($000) $2,557 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 131,551 Value ($000) $805 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 161,512 Value ($000) $2,655 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,806,243	$49,039	$24.89	$18.05 - $33.00
Q3 2025	272,271	$5,121	$15.54	$10.54 - $21.03
Q2 2025	232,887	$2,557	$9.24	$5.14 - $12.10
Q1 2025	131,551	$805	$9.55	$6.12 - $18.95
Q4 2024	161,512	$2,655	$22.33	$14.97 - $29.46