UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Schonfeld Strategic Advisors LLC's Holding History (CIK: 0001665241)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 115,807 Value ($000) $3,144 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 190,244 Value ($000) $3,578 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 365,790 Value ($000) $4,016 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 177,984 Value ($000) $1,089 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	115,807	$3,144	$24.89	$18.05 - $33.00
Q3 2025	190,244	$3,578	$15.54	$10.54 - $21.03
Q2 2025	365,790	$4,016	$9.24	$5.14 - $12.10
Q1 2025	177,984	$1,089	$9.55	$6.12 - $18.95