UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Caption Management, LLC's Holding History (CIK: 0001706766)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 18,196 Value ($000) $342 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	18,196	$342	$15.54	$10.54 - $21.03