UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Quantinno Capital Management LP's Holding History (CIK: 0001759654)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,415 Value ($000) $419 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 14,889 Value ($000) $280 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 10,614 Value ($000) $117 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 15,225 Value ($000) $93 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,415	$419	$24.89	$18.05 - $33.00
Q3 2025	14,889	$280	$15.54	$10.54 - $21.03
Q2 2025	10,614	$117	$9.24	$5.14 - $12.10
Q1 2025	15,225	$93	$9.55	$6.12 - $18.95