UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Y-Intercept (Hong Kong) Ltd's Holding History (CIK: 0001772875)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 46,559 Value ($000) $1,264 Avg Close $24.89 Range $18.05 - $33.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	46,559	$1,264	$24.89	$18.05 - $33.00