UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Parkman Healthcare Partners LLC's Holding History (CIK: 0001777015)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 834,559 Value ($000) $22,658 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 843,502 Value ($000) $15,866 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 715,504 Value ($000) $7,856 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 233,563 Value ($000) $1,429 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	834,559	$22,658	$24.89	$18.05 - $33.00
Q3 2025	843,502	$15,866	$15.54	$10.54 - $21.03
Q2 2025	715,504	$7,856	$9.24	$5.14 - $12.10
Q1 2025	233,563	$1,429	$9.55	$6.12 - $18.95