UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Ikarian Capital, LLC's Holding History (CIK: 0001778253)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 161,113 Value ($000) $3,031 Avg Close $15.54 Range $10.54 - $21.03

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	161,113	$3,031	$15.54	$10.54 - $21.03