UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Woodline Partners LP's Holding History (CIK: 0001784547)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 760,252 Value ($000) $20,641 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 602,252 Value ($000) $11,328 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 558,252 Value ($000) $6,130 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 557,063 Value ($000) $3,409 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 526,511 Value ($000) $8,656 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	760,252	$20,641	$24.89	$18.05 - $33.00
Q3 2025	602,252	$11,328	$15.54	$10.54 - $21.03
Q2 2025	558,252	$6,130	$9.24	$5.14 - $12.10
Q1 2025	557,063	$3,409	$9.55	$6.12 - $18.95
Q4 2024	526,511	$8,656	$22.33	$14.97 - $29.46