UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

XTX Topco Ltd's Holding History (CIK: 0001828301)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,091 Value ($000) $410 Avg Close $24.89 Range $18.05 - $33.00

Q1 2025

Shares 12,731 Value ($000) $78 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,091	$410	$24.89	$18.05 - $33.00
Q1 2025	12,731	$78	$9.55	$6.12 - $18.95