UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

TCG Crossover Management, LLC's Holding History (CIK: 0001839948)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 743,886 Value ($000) $20,197 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 2,117,103 Value ($000) $39,823 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 2,801,763 Value ($000) $30,763 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 2,801,763 Value ($000) $17,147 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 2,801,763 Value ($000) $44,856 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	743,886	$20,197	$24.89	$18.05 - $33.00
Q3 2025	2,117,103	$39,823	$15.54	$10.54 - $21.03
Q2 2025	2,801,763	$30,763	$9.24	$5.14 - $12.10
Q1 2025	2,801,763	$17,147	$9.55	$6.12 - $18.95
Q4 2024	2,801,763	$44,856	$22.33	$14.97 - $29.46