UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

Nuveen, LLC's Holding History (CIK: 0001871926)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 78,568 Value ($000) $2,133 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 69,882 Value ($000) $1,314 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 73,936 Value ($000) $812 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 22,586 Value ($000) $138 Avg Close $9.55 Range $6.12 - $18.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	78,568	$2,133	$24.89	$18.05 - $33.00
Q3 2025	69,882	$1,314	$15.54	$10.54 - $21.03
Q2 2025	73,936	$812	$9.24	$5.14 - $12.10
Q1 2025	22,586	$138	$9.55	$6.12 - $18.95