UPSTREAM BIO INC

Ticker: UPB CUSIP: 91678A107 Class: Common Stock

BlackRock, Inc.'s Holding History (CIK: 0002012383)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,344,504 Value ($000) $90,803 Avg Close $24.89 Range $18.05 - $33.00

Q3 2025

Shares 2,603,706 Value ($000) $48,976 Avg Close $15.54 Range $10.54 - $21.03

Q2 2025

Shares 2,096,506 Value ($000) $23,020 Avg Close $9.24 Range $5.14 - $12.10

Q1 2025

Shares 1,185,768 Value ($000) $7,257 Avg Close $9.55 Range $6.12 - $18.95

Q4 2024

Shares 1,117,800 Value ($000) $18,377 Avg Close $22.33 Range $14.97 - $29.46

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,344,504	$90,803	$24.89	$18.05 - $33.00
Q3 2025	2,603,706	$48,976	$15.54	$10.54 - $21.03
Q2 2025	2,096,506	$23,020	$9.24	$5.14 - $12.10
Q1 2025	1,185,768	$7,257	$9.55	$6.12 - $18.95
Q4 2024	1,117,800	$18,377	$22.33	$14.97 - $29.46