VAXCYTE INC

Ticker: PCVX CUSIP: 92243G108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 111,310 Value ($000) $5,136 Avg Close $44.73 Range $36.15 - $50.27

Q3 2025

Shares 107,587 Value ($000) $3,875 Avg Close $33.13 Range $29.08 - $37.95

Q2 2025

Shares 87,562 Value ($000) $2,847 Avg Close $32.78 Range $27.66 - $38.39

Q1 2023

Shares 238,398 Value ($000) $8,935 Avg Close $42.42 Range $35.76 - $49.31

Q4 2022

Shares 200,159 Value ($000) $9,598 Avg Close $39.24 Range $20.49 - $48.19

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	111,310	$5,136	$44.73	$36.15 - $50.27
Q3 2025	107,587	$3,875	$33.13	$29.08 - $37.95
Q2 2025	87,562	$2,847	$32.78	$27.66 - $38.39
Q1 2023	238,398	$8,935	$42.42	$35.76 - $49.31
Q4 2022	200,159	$9,598	$39.24	$20.49 - $48.19