| FMR LLC | 13,834,514 | $638,324 |
| JANUS HENDERSON GROUP PLC | 13,387,188 | $617,731 |
| VANGUARD GROUP INC | 12,193,986 | $562,631 |
| RA CAPITAL MANAGEMENT, L.P. | 10,724,599 | $494,833 |
| BlackRock, Inc. | 10,246,378 | $472,768 |
| T. Rowe Price Investment Management, Inc. | 6,682,676 | $308 |
| WELLINGTON MANAGEMENT GROUP LLP | 5,966,310 | $275,286 |
| STATE STREET CORP | 4,980,005 | $229,777 |
| Paradigm Biocapital Advisors LP | 4,068,020 | $187,698 |
| Deep Track Capital, LP | 4,000,000 | $184,560 |
| D. E. Shaw & Co., Inc. | 3,631,053 | $167,537 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,539,717 | $163,323 |
| Kynam Capital Management, LP | 2,922,335 | $134,837 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,866,305 | $132,271 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,725,000 | $79,592 |
| Caligan Partners LP | 1,704,815 | $78,660 |
| Polar Capital Holdings Plc | 1,672,783 | $77,182 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,372,425 | $63,324 |
| MAVERICK CAPITAL LTD | 1,354,237 | $62,484 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,293,830 | $59,697 |
| NORGES BANK | 1,228,939 | $56,703 |
| Eversept Partners, LP | 1,197,722 | $55,263 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,175,339 | $54 |
| UBS Group AG | 1,093,593 | $50,458 |
| JPMORGAN CHASE & CO | 1,085,519 | $50,086 |
| GOLDMAN SACHS GROUP INC | 1,078,120 | $49,744 |
| NORTHERN TRUST CORP | 1,034,180 | $47,717 |
| abrdn plc | 979,765 | $45,206 |
| EVENTIDE ASSET MANAGEMENT, LLC | 917,115 | $42,313 |
| Novo Holdings A/S | 916,160 | $42,272 |
| Pictet Asset Management Holding SA | 881,435 | $40,669 |
| Capital Research Global Investors | 842,978 | $38,895 |
| MORGAN STANLEY | 835,387 | $38,545 |
| Saturn V Capital Management LP | 798,940 | $36,863 |
| Trails Edge Capital Partners, LP | 737,470 | $34,027 |
| BANK OF AMERICA CORP /DE/ | 701,634 | $32,373 |
| JENNISON ASSOCIATES LLC | 677,553 | $31,262 |
| Logos Global Management LP | 650,000 | $29,991 |
| Soleus Capital Management, L.P. | 608,958 | $28,097 |
| BROWN ADVISORY INC | 566,925 | $26,158 |
| VICTORY CAPITAL MANAGEMENT INC | 549,514 | $25,355 |
| Assenagon Asset Management S.A. | 544,728 | $25,134 |
| Ensign Peak Advisors, Inc | 527,688 | $24,348 |
| FEDERATED HERMES, INC. | 523,489 | $24,154 |
| BOOTHBAY FUND MANAGEMENT, LLC | 497,740 | $22,966 |
| EcoR1 Capital, LLC | 450,000 | $20,763 |
| Bank of New York Mellon Corp | 449,363 | $20,734 |
| MILLENNIUM MANAGEMENT LLC | 424,294 | $19,577 |
| Spruce Street Capital LP | 400,360 | $18,473 |
| UBS ASSET MANAGEMENT AMERICAS INC | 389,010 | $17,949 |
| Ikarian Capital, LLC | 378,682 | $17,472 |
| TD Asset Management Inc | 363,734 | $16,783 |
| AMERICAN CENTURY COMPANIES INC | 357,300 | $16,486 |
| DEUTSCHE BANK AG\ | 342,894 | $15,821 |
| FRANKLIN RESOURCES INC | 336,143 | $15,510 |
| CITADEL ADVISORS LLC | 326,574 | $15,068 |
| ADAR1 Capital Management, LLC | 315,642 | $14,564 |
| Nuveen, LLC | 307,202 | $14,174 |
| AMERIPRISE FINANCIAL INC | 305,194 | $14,082 |
| Artisan Partners Limited Partnership | 304,049 | $14,029 |
| BARCLAYS PLC | 296,195 | $13,666 |
| Elmind Capital, LP | 291,500 | $13,450 |
| JANE STREET GROUP, LLC | 279,604 | $12,901 |
| TANG CAPITAL MANAGEMENT LLC | 275,000 | $12,689 |
| Woodline Partners LP | 274,740 | $12,677 |
| University of Wisconsin Foundation | 247,000 | $11,397 |
| Alyeska Investment Group, L.P. | 244,775 | $11,294 |
| CITIGROUP INC | 241,880 | $11,160 |
| Swiss National Bank | 230,400 | $10,631 |
| Qube Research & Technologies Ltd | 207,090 | $9,555 |
| C WorldWide Group Holding A/S | 195,000 | $9 |
| SEGALL BRYANT & HAMILL, LLC | 193,423 | $8,925 |
| DIMENSIONAL FUND ADVISORS LP | 191,786 | $8,849 |
| RAYMOND JAMES FINANCIAL INC | 185,851 | $8,455 |
| Point72 Asset Management, L.P. | 161,614 | $7,457 |
| RHUMBLINE ADVISERS | 150,919 | $6,963 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 148,787 | $6,865 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,603 | $6,672 |
| NAN FUNG TRINITY (HK) LTD | 142,930 | $6,595 |
| Invesco Ltd. | 141,220 | $6,516 |
| WELLS FARGO & COMPANY/MN | 134,075 | $6,186 |
| ALLIANCEBERNSTEIN L.P. | 133,882 | $6,177 |
| Rafferty Asset Management, LLC | 133,764 | $6,172 |
| READYSTATE ASSET MANAGEMENT LP | 131,637 | $6,074 |
| Cormorant Asset Management, LP | 125,000 | $5,768 |
| Legal & General Group Plc | 120,301 | $5,551 |
| NEW YORK STATE COMMON RETIREMENT FUND | 116,817 | $5,390 |
| HighVista Strategies LLC | 114,049 | $5,262 |
| HRT FINANCIAL LP | 113,950 | $5 |
| TWO SIGMA INVESTMENTS, LP | 111,310 | $5,136 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110,862 | $5,115 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108,445 | $4,966 |
| Creative Planning | 102,686 | $4,738 |
| NEXTBio Capital Management LP | 95,485 | $4,406 |
| Jump Financial, LLC | 89,822 | $4,144 |
| TWINBEECH CAPITAL LP | 78,239 | $3,610 |
| BANQUE PICTET & CIE SA | 71,815 | $3,314 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,124 | $3,236 |
| Man Group plc | 68,913 | $3,180 |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,285 | $3,151 |
| 193 other institutions | 2,338,595 | $94,776 |