VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

FRED ALGER MANAGEMENT, LLC's Holding History (CIK: 0000003520)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,433 Value ($000) $1,103 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 3,036 Value ($000) $1,189 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 6,173 Value ($000) $2,748 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 13,324 Value ($000) $6,460 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 5,262 Value ($000) $2,119 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 18,035 Value ($000) $8,388 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 60,203 Value ($000) $28,218 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 59,328 Value ($000) $24,800 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 213,507 Value ($000) $86,874 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 217,153 Value ($000) $75,513 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 202,677 Value ($000) $71,324 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 170,168 Value ($000) $53,615 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 404,865 Value ($000) $116,917 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 527,706 Value ($000) $152,792 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 498,339 Value ($000) $140,427 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 432,454 Value ($000) $112,858 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 389,546 Value ($000) $85,544 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 2,687 Value ($000) $487 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 2,806 Value ($000) $566 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 189,586 Value ($000) $40,740 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 564,097 Value ($000) $133,319 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 1,060,097 Value ($000) $288,474 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,114,582 Value ($000) $323,574 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,640,577 Value ($000) $390,375 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,618,643 Value ($000) $354,402 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 1,433,588 Value ($000) $242,878 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 1,334,542 Value ($000) $244,728 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,368,755 Value ($000) $251,782 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,990,714 Value ($000) $329,881 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,986,701 Value ($000) $382,917 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,960,493 Value ($000) $333,205 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 1,769,421 Value ($000) $288,380 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 2,018,898 Value ($000) $302,552 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,725,683 Value ($000) $262,373 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 1,624,480 Value ($000) $209,347 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1,209,979 Value ($000) $132,311 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 1,363,601 Value ($000) $100,456 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 1,609,897 Value ($000) $140,399 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 1,603,104 Value ($000) $137,899 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,968,489 Value ($000) $156,475 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 2,282,291 Value ($000) $287,180 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 2,439,867 Value ($000) $254,088 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 799,043 Value ($000) $98,666 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 308,569 Value ($000) $36,402 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 226,483 Value ($000) $26,906 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 365,181 Value ($000) $41,013 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 373,384 Value ($000) $35,352 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 742,085 Value ($000) $52,480 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 602,477 Value ($000) $44,764 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 715,515 Value ($000) $54,251 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 1,143,923 Value ($000) $91,582 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,433	$1,103	$431.03	$392.50 - $464.44
Q3 2025	3,036	$1,189	$417.92	$362.50 - $484.56
Q2 2025	6,173	$2,748	$460.83	$416.60 - $510.77
Q1 2025	13,324	$6,460	$466.00	$397.25 - $519.68
Q4 2024	5,262	$2,119	$463.53	$377.85 - $519.88
Q3 2024	18,035	$8,388	$480.37	$456.07 - $510.64
Q2 2024	60,203	$28,218	$434.05	$391.01 - $486.43
Q1 2024	59,328	$24,800	$422.74	$403.43 - $448.40
Q4 2023	213,507	$86,874	$369.42	$341.85 - $413.00
Q3 2023	217,153	$75,513	$349.73	$335.82 - $367.00
Q2 2023	202,677	$71,324	$336.94	$313.47 - $354.94
Q1 2023	170,168	$53,615	$299.93	$282.21 - $325.19
Q4 2022	404,865	$116,917	$304.77	$283.58 - $324.75
Q3 2022	527,706	$152,792	$287.72	$271.61 - $305.95
Q2 2022	498,339	$140,427	$267.66	$233.01 - $293.17
Q1 2022	432,454	$112,858	$237.33	$214.66 - $263.58
Q4 2021	389,546	$85,544	$194.45	$176.36 - $224.49
Q3 2021	2,687	$487	$195.24	$180.02 - $204.88
Q2 2021	2,806	$566	$209.17	$185.33 - $222.78
Q1 2021	189,586	$40,740	$219.65	$204.62 - $242.99
Q4 2020	564,097	$133,319	$229.44	$202.57 - $280.99
Q3 2020	1,060,097	$288,474	$275.88	$253.97 - $306.08
Q2 2020	1,114,582	$323,574	$271.12	$222.39 - $299.21
Q1 2020	1,640,577	$390,375	$229.39	$197.47 - $249.85
Q4 2019	1,618,643	$354,402	$202.38	$165.23 - $225.66
Q3 2019	1,433,588	$242,878	$176.91	$165.27 - $188.44
Q2 2019	1,334,542	$244,728	$174.82	$163.68 - $191.71
Q1 2019	1,368,755	$251,782	$184.70	$160.95 - $195.81
Q4 2018	1,990,714	$329,881	$173.27	$151.80 - $194.92
Q3 2018	1,986,701	$382,917	$178.07	$164.70 - $193.78
Q2 2018	1,960,493	$333,205	$155.01	$144.07 - $172.00
Q1 2018	1,769,421	$288,380	$163.34	$146.21 - $178.15
Q4 2017	2,018,898	$302,552	$148.07	$136.50 - $158.04
Q3 2017	1,725,683	$262,373	$150.51	$125.50 - $167.86
Q2 2017	1,624,480	$209,347	$120.38	$107.24 - $137.26
Q1 2017	1,209,979	$132,311	$88.04	$73.34 - $111.88
Q4 2016	1,363,601	$100,456	$81.37	$71.46 - $97.93
Q3 2016	1,609,897	$140,399	$94.50	$83.50 - $103.73
Q2 2016	1,603,104	$137,899	$86.41	$75.92 - $96.49
Q1 2016	1,968,489	$156,475	$90.45	$75.90 - $124.96
Q4 2015	2,282,291	$287,180	$120.72	$101.49 - $134.71
Q3 2015	2,439,867	$254,088	$128.47	$97.45 - $143.45
Q2 2015	799,043	$98,666	$125.98	$113.68 - $137.50
Q1 2015	308,569	$36,402	$119.81	$103.75 - $136.33
Q4 2014	226,483	$26,906	$112.63	$96.43 - $124.35
Q3 2014	365,181	$41,013	$95.21	$84.41 - $116.88
Q2 2014	373,384	$35,352	$70.12	$59.79 - $98.80
Q1 2014	742,085	$52,480	$79.20	$67.49 - $87.77
Q4 2013	602,477	$44,764	$69.64	$58.06 - $78.38
Q3 2013	715,515	$54,251	$79.58	$73.43 - $89.96
Q2 2013	1,143,923	$91,582	$73.64	$51.28 - $87.47