VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
Capital World Investors25,510,182$11,565,309
VANGUARD GROUP INC24,105,823$10,928,616
BlackRock, Inc.23,751,989$10,768,202
Capital Research Global Investors17,316,344$7,850,544
STATE STREET CORP11,689,539$5,299,569
JPMORGAN CHASE & CO6,039,481$2,738,059
GEODE CAPITAL MANAGEMENT, LLC5,981,905$2,700,208
Capital International Investors4,733,596$2,146,041
ALLIANCEBERNSTEIN L.P.4,496,482$2,038,525
LOOMIS SAYLES & CO L P4,033,525$1,828,639
WELLINGTON MANAGEMENT GROUP LLP3,821,731$1,732,620
VICTORY CAPITAL MANAGEMENT INC3,356,766$1,521,851
JENNISON ASSOCIATES LLC3,249,541$1,473,212
NORGES BANK3,176,613$1,440,149
MORGAN STANLEY3,120,310$1,414,625
UBS ASSET MANAGEMENT AMERICAS INC3,000,778$1,360,433
BANK OF AMERICA CORP /DE/2,937,030$1,331,532
Clearbridge Investments, LLC2,860,176$1,296,689
NORTHERN TRUST CORP2,579,457$1,169,423
PRICE T ROWE ASSOCIATES INC /MD/2,278,958$1,033
AMERIPRISE FINANCIAL INC2,263,732$1,026,287
JANUS HENDERSON GROUP PLC2,221,953$1,007,381
FMR LLC2,212,596$1,003,102
Invesco Ltd.2,152,672$975,935
Legal & General Group Plc1,970,105$893,167
CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,859,221$842,896
DEUTSCHE BANK AG\1,768,881$801,940
GOLDMAN SACHS GROUP INC1,754,118$795,247
Bank of New York Mellon Corp1,527,586$692,546
Amundi1,304,161$591,254
ROYAL BANK OF CANADA1,194,512$541,544
WCM INVESTMENT MANAGEMENT, LLC1,129,145$512,338
EDGEWOOD MANAGEMENT LLC1,060,075$480,596
Nuveen, LLC1,042,397$472,581
DIMENSIONAL FUND ADVISORS LP945,660$428,726
Winslow Capital Management, LLC887,640$405,098
AMERICAN CENTURY COMPANIES INC848,639$384,739
BARCLAYS PLC847,758$384,340
Assenagon Asset Management S.A.832,853$377,582
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt803,773$364,400
Pictet Asset Management Holding SA752,425$342,202
WELLS FARGO & COMPANY/MN741,813$336,308
Swiss National Bank702,600$318,531
Bellevue Group AG681,120$308,793
BNP Paribas Investment Partners S.A.669,807$304
Sumitomo Mitsui Trust Holdings, Inc.654,470$296,711
HSBC HOLDINGS PLC630,289$285,886
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP593,947$269,272
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.566,227$256,008
Voya Investment Management LLC562,352$254,372
BNP PARIBAS ARBITRAGE, SA559,543$253,674
MANUFACTURERS LIFE INSURANCE COMPANY, THE557,713$252,880
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM556,064$252,097
UBS Group AG555,982$252,060
FRANKLIN RESOURCES INC550,600$249,620
NEUBERGER BERMAN GROUP LLC545,897$247,488
CITIGROUP INC539,930$244,783
National Pension Service530,841$240,662
NATIXIS ADVISORS, L.P.527,864$239
B. Metzler seel. Sohn & Co. AG515,269$233,583
DekaBank Deutsche Girozentrale506,457$220
RENAISSANCE TECHNOLOGIES LLC505,048$228,969
ENVESTNET ASSET MANAGEMENT INC471,643$213,824
ProShare Advisors LLC457,046$207,206
NORDEA INVESTMENT MANAGEMENT AB447,169$202,612
RHUMBLINE ADVISERS431,262$195,517
Manning & Napier Advisors LLC427,603$194,021
BANK OF MONTREAL /CAN/427,480$193,802
CITADEL ADVISORS LLC427,060$193,612
RAYMOND JAMES FINANCIAL INC418,131$189,564
PRINCIPAL FINANCIAL GROUP INC415,100$188,190
Chevy Chase Trust Holdings, LLC408,363$185,135
Robeco Institutional Asset Management B.V.394,200$178,715
HARDING LOEVNER LP391,865$177,661
Squarepoint Ops LLC389,020$176,366
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM385,751$174,884
Russell Investments Group, Ltd.381,462$172,956
Man Group plc380,735$172,610
Life Cycle Investment Partners Ltd366,854$166,317
Bank Julius Baer & Co. Ltd, Zurich366,341$166,111
MILLENNIUM MANAGEMENT LLC365,664$165,777
SEI INVESTMENTS CO364,023$165,033
Alyeska Investment Group, L.P.354,334$160,641
Zurcher Kantonalbank (Zurich Cantonalbank)353,488$160,257
Connor, Clark & Lunn Investment Management Ltd.345,383$156,583
Universal- Beteiligungs- und Servicegesellschaft mbH334,898$151,802
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO329,745$149
Ensign Peak Advisors, Inc303,784$137,724
NEW YORK STATE COMMON RETIREMENT FUND297,414$134,836
LOS ANGELES CAPITAL MANAGEMENT LLC293,301$123,154
LPL Financial LLC276,878$125,525
ROYAL LONDON ASSET MANAGEMENT LTD273,433$123,964
ADAGE CAPITAL PARTNERS GP, L.L.C.272,474$123,529
abrdn plc262,057$118,806
Cerity Partners LLC261,553$118,577
Swedbank AB260,743$118,210
NATIONAL BANK OF CANADA /FI/238,548$108,145
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM226,000$102,459
Candriam S.C.A.225,292$102,143
WELCH & FORBES LLC218,198$98,922
1530 other institutions22,670,958$9,207,435
Total (1,630 institutions)235,589,214$103,764,415