VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

US BANCORP \DE\'s Holding History (CIK: 0000036104)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 29,850 Value ($000) $13,533 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 30,856 Value ($000) $12,084 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 33,583 Value ($000) $14,951 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 32,259 Value ($000) $15,640 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 30,343 Value ($000) $12,219 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 26,579 Value ($000) $12,361 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 24,306 Value ($000) $11,393 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 21,450 Value ($000) $8,966 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 19,162 Value ($000) $7,797 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 13,097 Value ($000) $4,554 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 11,714 Value ($000) $4,122 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 12,629 Value ($000) $3,979 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 12,446 Value ($000) $3,594 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 13,172 Value ($000) $3,812 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 12,594 Value ($000) $3,549 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 15,701 Value ($000) $4,097 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 14,189 Value ($000) $3,116 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 12,294 Value ($000) $2,230 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 12,768 Value ($000) $2,575 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 16,176 Value ($000) $3,477 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 14,108 Value ($000) $3,334 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 13,186 Value ($000) $3,589 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 12,214 Value ($000) $3,546 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 12,542 Value ($000) $2,984 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 10,490 Value ($000) $2,296 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 10,013 Value ($000) $1,696 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 9,306 Value ($000) $1,706 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 8,987 Value ($000) $1,653 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 8,302 Value ($000) $1,376 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 7,251 Value ($000) $1,398 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 7,369 Value ($000) $1,253 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 8,684 Value ($000) $1,416 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 7,015 Value ($000) $1,051 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 7,197 Value ($000) $1,094 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 6,741 Value ($000) $869 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 7,324 Value ($000) $801 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 3,575 Value ($000) $263 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 17,536 Value ($000) $1,529 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 13,751 Value ($000) $1,182 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 3,221 Value ($000) $256 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 4,602 Value ($000) $579 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 5,317 Value ($000) $554 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 4,291 Value ($000) $530 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 3,563 Value ($000) $420 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 2,791 Value ($000) $331 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 1,677 Value ($000) $189 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 1,787 Value ($000) $170 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 435 Value ($000) $31 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 1,642 Value ($000) $122 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 5,549 Value ($000) $421 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 663 Value ($000) $53 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	29,850	$13,533	$431.03	$392.50 - $464.44
Q3 2025	30,856	$12,084	$417.92	$362.50 - $484.56
Q2 2025	33,583	$14,951	$460.83	$416.60 - $510.77
Q1 2025	32,259	$15,640	$466.00	$397.25 - $519.68
Q4 2024	30,343	$12,219	$463.53	$377.85 - $519.88
Q3 2024	26,579	$12,361	$480.37	$456.07 - $510.64
Q2 2024	24,306	$11,393	$434.05	$391.01 - $486.43
Q1 2024	21,450	$8,966	$422.74	$403.43 - $448.40
Q4 2023	19,162	$7,797	$369.42	$341.85 - $413.00
Q3 2023	13,097	$4,554	$349.73	$335.82 - $367.00
Q2 2023	11,714	$4,122	$336.94	$313.47 - $354.94
Q1 2023	12,629	$3,979	$299.93	$282.21 - $325.19
Q4 2022	12,446	$3,594	$304.77	$283.58 - $324.75
Q3 2022	13,172	$3,812	$287.72	$271.61 - $305.95
Q2 2022	12,594	$3,549	$267.66	$233.01 - $293.17
Q1 2022	15,701	$4,097	$237.33	$214.66 - $263.58
Q4 2021	14,189	$3,116	$194.45	$176.36 - $224.49
Q3 2021	12,294	$2,230	$195.24	$180.02 - $204.88
Q2 2021	12,768	$2,575	$209.17	$185.33 - $222.78
Q1 2021	16,176	$3,477	$219.65	$204.62 - $242.99
Q4 2020	14,108	$3,334	$229.44	$202.57 - $280.99
Q3 2020	13,186	$3,589	$275.88	$253.97 - $306.08
Q2 2020	12,214	$3,546	$271.12	$222.39 - $299.21
Q1 2020	12,542	$2,984	$229.39	$197.47 - $249.85
Q4 2019	10,490	$2,296	$202.38	$165.23 - $225.66
Q3 2019	10,013	$1,696	$176.91	$165.27 - $188.44
Q2 2019	9,306	$1,706	$174.82	$163.68 - $191.71
Q1 2019	8,987	$1,653	$184.70	$160.95 - $195.81
Q4 2018	8,302	$1,376	$173.27	$151.80 - $194.92
Q3 2018	7,251	$1,398	$178.07	$164.70 - $193.78
Q2 2018	7,369	$1,253	$155.01	$144.07 - $172.00
Q1 2018	8,684	$1,416	$163.34	$146.21 - $178.15
Q4 2017	7,015	$1,051	$148.07	$136.50 - $158.04
Q3 2017	7,197	$1,094	$150.51	$125.50 - $167.86
Q2 2017	6,741	$869	$120.38	$107.24 - $137.26
Q1 2017	7,324	$801	$88.04	$73.34 - $111.88
Q4 2016	3,575	$263	$81.37	$71.46 - $97.93
Q3 2016	17,536	$1,529	$94.50	$83.50 - $103.73
Q2 2016	13,751	$1,182	$86.41	$75.92 - $96.49
Q1 2016	3,221	$256	$90.45	$75.90 - $124.96
Q4 2015	4,602	$579	$120.72	$101.49 - $134.71
Q3 2015	5,317	$554	$128.47	$97.45 - $143.45
Q2 2015	4,291	$530	$125.98	$113.68 - $137.50
Q1 2015	3,563	$420	$119.81	$103.75 - $136.33
Q4 2014	2,791	$331	$112.63	$96.43 - $124.35
Q3 2014	1,677	$189	$95.21	$84.41 - $116.88
Q2 2014	1,787	$170	$70.12	$59.79 - $98.80
Q1 2014	435	$31	$79.20	$67.49 - $87.77
Q4 2013	1,642	$122	$69.64	$58.06 - $78.38
Q3 2013	5,549	$421	$79.58	$73.43 - $89.96
Q2 2013	663	$53	$73.64	$51.28 - $87.47