VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Manning & Napier Advisors LLC's Holding History (CIK: 0000062039)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 427,603 Value ($000) $194,021 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 474,822 Value ($000) $187,702 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 233,580 Value ($000) $103,992 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 235,108 Value ($000) $113,985 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 150,126 Value ($000) $60,456 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 155,761 Value ($000) $72,441 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 158,332 Value ($000) $74,213 Avg Close $434.05 Range $391.01 - $486.43

Q3 2017

Shares 885,868 Value ($000) $134,686 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 1,631,126 Value ($000) $210,201 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1,764,419 Value ($000) $192,938 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 2,126,020 Value ($000) $156,623 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 142,540 Value ($000) $12,430 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 126,990 Value ($000) $10,922 Avg Close $86.41 Range $75.92 - $96.49

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	427,603	$194,021	$431.03	$392.50 - $464.44
Q3 2025	474,822	$187,702	$417.92	$362.50 - $484.56
Q2 2025	233,580	$103,992	$460.83	$416.60 - $510.77
Q1 2025	235,108	$113,985	$466.00	$397.25 - $519.68
Q4 2024	150,126	$60,456	$463.53	$377.85 - $519.88
Q3 2024	155,761	$72,441	$480.37	$456.07 - $510.64
Q2 2024	158,332	$74,213	$434.05	$391.01 - $486.43
Q3 2017	885,868	$134,686	$150.51	$125.50 - $167.86
Q2 2017	1,631,126	$210,201	$120.38	$107.24 - $137.26
Q1 2017	1,764,419	$192,938	$88.04	$73.34 - $111.88
Q4 2016	2,126,020	$156,623	$81.37	$71.46 - $97.93
Q3 2016	142,540	$12,430	$94.50	$83.50 - $103.73
Q2 2016	126,990	$10,922	$86.41	$75.92 - $96.49