VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

WELLS FARGO & COMPANY/MN's Holding History (CIK: 0000072971)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 741,813 Value ($000) $336,308 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 717,326 Value ($000) $280,934 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 702,052 Value ($000) $312,554 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 706,169 Value ($000) $342,365 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 689,652 Value ($000) $277,723 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 830,220 Value ($000) $386,119 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 818,364 Value ($000) $383,584 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 767,567 Value ($000) $320,851 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 748,966 Value ($000) $304,747 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 780,287 Value ($000) $271,337 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 807,615 Value ($000) $284,208 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 782,108 Value ($000) $246,419 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 748,927 Value ($000) $216,275 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 778,271 Value ($000) $225,341 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 799,702 Value ($000) $225,348 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 851,082 Value ($000) $222,106 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 845,804 Value ($000) $185,739 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,131,591 Value ($000) $205,259 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,173,380 Value ($000) $236,589 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,230,059 Value ($000) $264,328 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,305,144 Value ($000) $308,458 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 1,475,350 Value ($000) $401,473 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,527,048 Value ($000) $443,317 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,339,784 Value ($000) $318,801 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,325,652 Value ($000) $290,251 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 1,370,387 Value ($000) $232,172 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 1,481,996 Value ($000) $271,768 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,577,416 Value ($000) $290,165 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,910,003 Value ($000) $316,507 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 2,151,713 Value ($000) $414,720 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 2,087,508 Value ($000) $354,794 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 2,004,697 Value ($000) $326,725 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 2,127,092 Value ($000) $318,765 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,977,269 Value ($000) $300,624 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 1,916,227 Value ($000) $246,944 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1,832,913 Value ($000) $200,429 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 1,531,238 Value ($000) $112,807 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 1,641,196 Value ($000) $143,129 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 1,827,750 Value ($000) $157,224 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,979,217 Value ($000) $157,328 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 2,610,825 Value ($000) $328,521 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 1,170,624 Value ($000) $121,908 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 1,274,505 Value ($000) $157,381 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 1,297,174 Value ($000) $153,025 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 1,664,943 Value ($000) $197,804 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 1,290,134 Value ($000) $144,860 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 673,158 Value ($000) $63,736 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 1,731,349 Value ($000) $122,434 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 2,185,923 Value ($000) $162,414 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 2,006,497 Value ($000) $152,133 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 1,903,231 Value ($000) $152,373 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	741,813	$336,308	$431.03	$392.50 - $464.44
Q3 2025	717,326	$280,934	$417.92	$362.50 - $484.56
Q2 2025	702,052	$312,554	$460.83	$416.60 - $510.77
Q1 2025	706,169	$342,365	$466.00	$397.25 - $519.68
Q4 2024	689,652	$277,723	$463.53	$377.85 - $519.88
Q3 2024	830,220	$386,119	$480.37	$456.07 - $510.64
Q2 2024	818,364	$383,584	$434.05	$391.01 - $486.43
Q1 2024	767,567	$320,851	$422.74	$403.43 - $448.40
Q4 2023	748,966	$304,747	$369.42	$341.85 - $413.00
Q3 2023	780,287	$271,337	$349.73	$335.82 - $367.00
Q2 2023	807,615	$284,208	$336.94	$313.47 - $354.94
Q1 2023	782,108	$246,419	$299.93	$282.21 - $325.19
Q4 2022	748,927	$216,275	$304.77	$283.58 - $324.75
Q3 2022	778,271	$225,341	$287.72	$271.61 - $305.95
Q2 2022	799,702	$225,348	$267.66	$233.01 - $293.17
Q1 2022	851,082	$222,106	$237.33	$214.66 - $263.58
Q4 2021	845,804	$185,739	$194.45	$176.36 - $224.49
Q3 2021	1,131,591	$205,259	$195.24	$180.02 - $204.88
Q2 2021	1,173,380	$236,589	$209.17	$185.33 - $222.78
Q1 2021	1,230,059	$264,328	$219.65	$204.62 - $242.99
Q4 2020	1,305,144	$308,458	$229.44	$202.57 - $280.99
Q3 2020	1,475,350	$401,473	$275.88	$253.97 - $306.08
Q2 2020	1,527,048	$443,317	$271.12	$222.39 - $299.21
Q1 2020	1,339,784	$318,801	$229.39	$197.47 - $249.85
Q4 2019	1,325,652	$290,251	$202.38	$165.23 - $225.66
Q3 2019	1,370,387	$232,172	$176.91	$165.27 - $188.44
Q2 2019	1,481,996	$271,768	$174.82	$163.68 - $191.71
Q1 2019	1,577,416	$290,165	$184.70	$160.95 - $195.81
Q4 2018	1,910,003	$316,507	$173.27	$151.80 - $194.92
Q3 2018	2,151,713	$414,720	$178.07	$164.70 - $193.78
Q2 2018	2,087,508	$354,794	$155.01	$144.07 - $172.00
Q1 2018	2,004,697	$326,725	$163.34	$146.21 - $178.15
Q4 2017	2,127,092	$318,765	$148.07	$136.50 - $158.04
Q3 2017	1,977,269	$300,624	$150.51	$125.50 - $167.86
Q2 2017	1,916,227	$246,944	$120.38	$107.24 - $137.26
Q1 2017	1,832,913	$200,429	$88.04	$73.34 - $111.88
Q4 2016	1,531,238	$112,807	$81.37	$71.46 - $97.93
Q3 2016	1,641,196	$143,129	$94.50	$83.50 - $103.73
Q2 2016	1,827,750	$157,224	$86.41	$75.92 - $96.49
Q1 2016	1,979,217	$157,328	$90.45	$75.90 - $124.96
Q4 2015	2,610,825	$328,521	$120.72	$101.49 - $134.71
Q3 2015	1,170,624	$121,908	$128.47	$97.45 - $143.45
Q2 2015	1,274,505	$157,381	$125.98	$113.68 - $137.50
Q1 2015	1,297,174	$153,025	$119.81	$103.75 - $136.33
Q4 2014	1,664,943	$197,804	$112.63	$96.43 - $124.35
Q3 2014	1,290,134	$144,860	$95.21	$84.41 - $116.88
Q2 2014	673,158	$63,736	$70.12	$59.79 - $98.80
Q1 2014	1,731,349	$122,434	$79.20	$67.49 - $87.77
Q4 2013	2,185,923	$162,414	$69.64	$58.06 - $78.38
Q3 2013	2,006,497	$152,133	$79.58	$73.43 - $89.96
Q2 2013	1,903,231	$152,373	$73.64	$51.28 - $87.47