VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

WELCH & FORBES LLC's Holding History (CIK: 0000105495)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 218,198 Value ($000) $98,922 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 220,346 Value ($000) $86,296 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 217,244 Value ($000) $96,717 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 207,639 Value ($000) $100,668 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 197,781 Value ($000) $79,647 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 196,619 Value ($000) $91,444 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 194,897 Value ($000) $94,286 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 192,941 Value ($000) $80,651 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 188,387 Value ($000) $76,653 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 185,070 Value ($000) $64,356 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 184,804 Value ($000) $65,034 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 186,218 Value ($000) $58,672 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 188,171 Value ($000) $54,340 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 189,458 Value ($000) $54,856 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 192,233 Value ($000) $54,170 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 195,558 Value ($000) $51,035 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 189,930 Value ($000) $41,708 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 202,037 Value ($000) $36,648 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 206,369 Value ($000) $41,611 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 209,680 Value ($000) $45,058 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 191,368 Value ($000) $45,228 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 184,682 Value ($000) $50,255 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 186,498 Value ($000) $54,143 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 182,367 Value ($000) $43,394 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 174,868 Value ($000) $38,288 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 176,514 Value ($000) $29,906 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 175,927 Value ($000) $32,261 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 174,450 Value ($000) $32,090 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 176,050 Value ($000) $29,174 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 176,436 Value ($000) $34,006 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 172,591 Value ($000) $29,334 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 177,041 Value ($000) $28,854 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 178,253 Value ($000) $26,713 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 180,674 Value ($000) $27,469 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 186,425 Value ($000) $24,024 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 185,774 Value ($000) $20,314 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 189,893 Value ($000) $13,990 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 192,660 Value ($000) $16,803 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 197,902 Value ($000) $17,024 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 194,169 Value ($000) $15,435 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 193,605 Value ($000) $24,362 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 193,306 Value ($000) $20,131 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 194,111 Value ($000) $23,968 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 203,964 Value ($000) $24,061 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 206,778 Value ($000) $24,565 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 211,823 Value ($000) $23,790 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 212,554 Value ($000) $20,125 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 222,860 Value ($000) $15,761 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 224,892 Value ($000) $16,710 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 238,733 Value ($000) $18,101 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 250,598 Value ($000) $20,064 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	218,198	$98,922	$431.03	$392.50 - $464.44
Q3 2025	220,346	$86,296	$417.92	$362.50 - $484.56
Q2 2025	217,244	$96,717	$460.83	$416.60 - $510.77
Q1 2025	207,639	$100,668	$466.00	$397.25 - $519.68
Q4 2024	197,781	$79,647	$463.53	$377.85 - $519.88
Q3 2024	196,619	$91,444	$480.37	$456.07 - $510.64
Q2 2024	194,897	$94,286	$434.05	$391.01 - $486.43
Q1 2024	192,941	$80,651	$422.74	$403.43 - $448.40
Q4 2023	188,387	$76,653	$369.42	$341.85 - $413.00
Q3 2023	185,070	$64,356	$349.73	$335.82 - $367.00
Q2 2023	184,804	$65,034	$336.94	$313.47 - $354.94
Q1 2023	186,218	$58,672	$299.93	$282.21 - $325.19
Q4 2022	188,171	$54,340	$304.77	$283.58 - $324.75
Q3 2022	189,458	$54,856	$287.72	$271.61 - $305.95
Q2 2022	192,233	$54,170	$267.66	$233.01 - $293.17
Q1 2022	195,558	$51,035	$237.33	$214.66 - $263.58
Q4 2021	189,930	$41,708	$194.45	$176.36 - $224.49
Q3 2021	202,037	$36,648	$195.24	$180.02 - $204.88
Q2 2021	206,369	$41,611	$209.17	$185.33 - $222.78
Q1 2021	209,680	$45,058	$219.65	$204.62 - $242.99
Q4 2020	191,368	$45,228	$229.44	$202.57 - $280.99
Q3 2020	184,682	$50,255	$275.88	$253.97 - $306.08
Q2 2020	186,498	$54,143	$271.12	$222.39 - $299.21
Q1 2020	182,367	$43,394	$229.39	$197.47 - $249.85
Q4 2019	174,868	$38,288	$202.38	$165.23 - $225.66
Q3 2019	176,514	$29,906	$176.91	$165.27 - $188.44
Q2 2019	175,927	$32,261	$174.82	$163.68 - $191.71
Q1 2019	174,450	$32,090	$184.70	$160.95 - $195.81
Q4 2018	176,050	$29,174	$173.27	$151.80 - $194.92
Q3 2018	176,436	$34,006	$178.07	$164.70 - $193.78
Q2 2018	172,591	$29,334	$155.01	$144.07 - $172.00
Q1 2018	177,041	$28,854	$163.34	$146.21 - $178.15
Q4 2017	178,253	$26,713	$148.07	$136.50 - $158.04
Q3 2017	180,674	$27,469	$150.51	$125.50 - $167.86
Q2 2017	186,425	$24,024	$120.38	$107.24 - $137.26
Q1 2017	185,774	$20,314	$88.04	$73.34 - $111.88
Q4 2016	189,893	$13,990	$81.37	$71.46 - $97.93
Q3 2016	192,660	$16,803	$94.50	$83.50 - $103.73
Q2 2016	197,902	$17,024	$86.41	$75.92 - $96.49
Q1 2016	194,169	$15,435	$90.45	$75.90 - $124.96
Q4 2015	193,605	$24,362	$120.72	$101.49 - $134.71
Q3 2015	193,306	$20,131	$128.47	$97.45 - $143.45
Q2 2015	194,111	$23,968	$125.98	$113.68 - $137.50
Q1 2015	203,964	$24,061	$119.81	$103.75 - $136.33
Q4 2014	206,778	$24,565	$112.63	$96.43 - $124.35
Q3 2014	211,823	$23,790	$95.21	$84.41 - $116.88
Q2 2014	212,554	$20,125	$70.12	$59.79 - $98.80
Q1 2014	222,860	$15,761	$79.20	$67.49 - $87.77
Q4 2013	224,892	$16,710	$69.64	$58.06 - $78.38
Q3 2013	238,733	$18,101	$79.58	$73.43 - $89.96
Q2 2013	250,598	$20,064	$73.64	$51.28 - $87.47