VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

NEW YORK STATE TEACHERS RETIREMENT SYSTEM's Holding History (CIK: 0000314969)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 211,092 Value ($000) $96 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 212,829 Value ($000) $83 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 203,504 Value ($000) $91 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 204,890 Value ($000) $99 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 221,252 Value ($000) $89 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 231,981 Value ($000) $108 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 255,596 Value ($000) $120 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 266,302 Value ($000) $111 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 272,690 Value ($000) $111 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 279,752 Value ($000) $97 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 290,386 Value ($000) $102 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 299,249 Value ($000) $94 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 310,010 Value ($000) $90 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 315,110 Value ($000) $91,237 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 323,268 Value ($000) $91,094 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 323,268 Value ($000) $84,363 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 324,548 Value ($000) $71,271 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 328,526 Value ($000) $59,591 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 341,634 Value ($000) $68,884 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 354,902 Value ($000) $76,265 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 364,938 Value ($000) $86,249 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 361,465 Value ($000) $98,362 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 373,291 Value ($000) $108,370 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 366,259 Value ($000) $87,151 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 366,159 Value ($000) $80,171 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 364,952 Value ($000) $61,830 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 365,696 Value ($000) $67,061 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 373,485 Value ($000) $68,703 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 369,431 Value ($000) $61,218 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 378,331 Value ($000) $72,920 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 383,464 Value ($000) $65,174 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 389,606 Value ($000) $63,498 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 393,945 Value ($000) $59,037 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 393,896 Value ($000) $59,888 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 388,907 Value ($000) $50,118 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 403,768 Value ($000) $44,152 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 411,378 Value ($000) $30,306 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 417,288 Value ($000) $36,392 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 422,451 Value ($000) $36,339 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 422,361 Value ($000) $33,573 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 422,297 Value ($000) $53,138 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 424,698 Value ($000) $44,228 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 423,913 Value ($000) $52,345 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 426,556 Value ($000) $50,321 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 425,809 Value ($000) $50,586 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 430,080 Value ($000) $48,302 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 437,502 Value ($000) $41,423 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 442,149 Value ($000) $31,269 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 443,913 Value ($000) $32,983 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 445,509 Value ($000) $33,778 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 420,000 Value ($000) $33,625 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	211,092	$96	$431.03	$392.50 - $464.44
Q3 2025	212,829	$83	$417.92	$362.50 - $484.56
Q2 2025	203,504	$91	$460.83	$416.60 - $510.77
Q1 2025	204,890	$99	$466.00	$397.25 - $519.68
Q4 2024	221,252	$89	$463.53	$377.85 - $519.88
Q3 2024	231,981	$108	$480.37	$456.07 - $510.64
Q2 2024	255,596	$120	$434.05	$391.01 - $486.43
Q1 2024	266,302	$111	$422.74	$403.43 - $448.40
Q4 2023	272,690	$111	$369.42	$341.85 - $413.00
Q3 2023	279,752	$97	$349.73	$335.82 - $367.00
Q2 2023	290,386	$102	$336.94	$313.47 - $354.94
Q1 2023	299,249	$94	$299.93	$282.21 - $325.19
Q4 2022	310,010	$90	$304.77	$283.58 - $324.75
Q3 2022	315,110	$91,237	$287.72	$271.61 - $305.95
Q2 2022	323,268	$91,094	$267.66	$233.01 - $293.17
Q1 2022	323,268	$84,363	$237.33	$214.66 - $263.58
Q4 2021	324,548	$71,271	$194.45	$176.36 - $224.49
Q3 2021	328,526	$59,591	$195.24	$180.02 - $204.88
Q2 2021	341,634	$68,884	$209.17	$185.33 - $222.78
Q1 2021	354,902	$76,265	$219.65	$204.62 - $242.99
Q4 2020	364,938	$86,249	$229.44	$202.57 - $280.99
Q3 2020	361,465	$98,362	$275.88	$253.97 - $306.08
Q2 2020	373,291	$108,370	$271.12	$222.39 - $299.21
Q1 2020	366,259	$87,151	$229.39	$197.47 - $249.85
Q4 2019	366,159	$80,171	$202.38	$165.23 - $225.66
Q3 2019	364,952	$61,830	$176.91	$165.27 - $188.44
Q2 2019	365,696	$67,061	$174.82	$163.68 - $191.71
Q1 2019	373,485	$68,703	$184.70	$160.95 - $195.81
Q4 2018	369,431	$61,218	$173.27	$151.80 - $194.92
Q3 2018	378,331	$72,920	$178.07	$164.70 - $193.78
Q2 2018	383,464	$65,174	$155.01	$144.07 - $172.00
Q1 2018	389,606	$63,498	$163.34	$146.21 - $178.15
Q4 2017	393,945	$59,037	$148.07	$136.50 - $158.04
Q3 2017	393,896	$59,888	$150.51	$125.50 - $167.86
Q2 2017	388,907	$50,118	$120.38	$107.24 - $137.26
Q1 2017	403,768	$44,152	$88.04	$73.34 - $111.88
Q4 2016	411,378	$30,306	$81.37	$71.46 - $97.93
Q3 2016	417,288	$36,392	$94.50	$83.50 - $103.73
Q2 2016	422,451	$36,339	$86.41	$75.92 - $96.49
Q1 2016	422,361	$33,573	$90.45	$75.90 - $124.96
Q4 2015	422,297	$53,138	$120.72	$101.49 - $134.71
Q3 2015	424,698	$44,228	$128.47	$97.45 - $143.45
Q2 2015	423,913	$52,345	$125.98	$113.68 - $137.50
Q1 2015	426,556	$50,321	$119.81	$103.75 - $136.33
Q4 2014	425,809	$50,586	$112.63	$96.43 - $124.35
Q3 2014	430,080	$48,302	$95.21	$84.41 - $116.88
Q2 2014	437,502	$41,423	$70.12	$59.79 - $98.80
Q1 2014	442,149	$31,269	$79.20	$67.49 - $87.77
Q4 2013	443,913	$32,983	$69.64	$58.06 - $78.38
Q3 2013	445,509	$33,778	$79.58	$73.43 - $89.96
Q2 2013	420,000	$33,625	$73.64	$51.28 - $87.47