VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

DIMENSIONAL FUND ADVISORS LP's Holding History (CIK: 0000354204)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 945,660 Value ($000) $428,726 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 783,586 Value ($000) $306,909 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 596,227 Value ($000) $265,417 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 605,879 Value ($000) $293,780 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 627,517 Value ($000) $252,685 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 647,808 Value ($000) $301,271 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 662,957 Value ($000) $310,768 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 587,912 Value ($000) $245,753 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 585,216 Value ($000) $238,128 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 592,395 Value ($000) $206,013 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 610,699 Value ($000) $214,903 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 620,815 Value ($000) $195,593 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 780,502 Value ($000) $225 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 864,307 Value ($000) $250,265 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 881,645 Value ($000) $248,425 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 953,174 Value ($000) $248,718 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 934,033 Value ($000) $205,133 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 704,546 Value ($000) $127,807 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 519,023 Value ($000) $104,638 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 469,611 Value ($000) $100,971 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 454,549 Value ($000) $107,419 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 435,575 Value ($000) $118,523 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 431,950 Value ($000) $125,387 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 396,850 Value ($000) $94,412 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 374,425 Value ($000) $81,981 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 372,573 Value ($000) $63,120 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 371,517 Value ($000) $68,126 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 365,512 Value ($000) $67,233 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 325,085 Value ($000) $53,860 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 313,237 Value ($000) $60,364 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 321,346 Value ($000) $54,569 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 321,146 Value ($000) $52,340 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 312,506 Value ($000) $46,835 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 296,881 Value ($000) $45,134 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 282,815 Value ($000) $36,445 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 272,933 Value ($000) $29,842 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 267,437 Value ($000) $19,703 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 258,913 Value ($000) $22,577 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 249,017 Value ($000) $21,419 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 248,207 Value ($000) $19,728 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 239,624 Value ($000) $30,153 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 225,605 Value ($000) $23,489 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 225,718 Value ($000) $27,871 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 231,374 Value ($000) $27,300 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 230,257 Value ($000) $27,356 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 227,938 Value ($000) $25,604 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 225,775 Value ($000) $21,373 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 226,298 Value ($000) $16,005 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 223,643 Value ($000) $16,616 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 207,369 Value ($000) $15,722 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 146,688 Value ($000) $11,718 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	945,660	$428,726	$431.03	$392.50 - $464.44
Q3 2025	783,586	$306,909	$417.92	$362.50 - $484.56
Q2 2025	596,227	$265,417	$460.83	$416.60 - $510.77
Q1 2025	605,879	$293,780	$466.00	$397.25 - $519.68
Q4 2024	627,517	$252,685	$463.53	$377.85 - $519.88
Q3 2024	647,808	$301,271	$480.37	$456.07 - $510.64
Q2 2024	662,957	$310,768	$434.05	$391.01 - $486.43
Q1 2024	587,912	$245,753	$422.74	$403.43 - $448.40
Q4 2023	585,216	$238,128	$369.42	$341.85 - $413.00
Q3 2023	592,395	$206,013	$349.73	$335.82 - $367.00
Q2 2023	610,699	$214,903	$336.94	$313.47 - $354.94
Q1 2023	620,815	$195,593	$299.93	$282.21 - $325.19
Q4 2022	780,502	$225	$304.77	$283.58 - $324.75
Q3 2022	864,307	$250,265	$287.72	$271.61 - $305.95
Q2 2022	881,645	$248,425	$267.66	$233.01 - $293.17
Q1 2022	953,174	$248,718	$237.33	$214.66 - $263.58
Q4 2021	934,033	$205,133	$194.45	$176.36 - $224.49
Q3 2021	704,546	$127,807	$195.24	$180.02 - $204.88
Q2 2021	519,023	$104,638	$209.17	$185.33 - $222.78
Q1 2021	469,611	$100,971	$219.65	$204.62 - $242.99
Q4 2020	454,549	$107,419	$229.44	$202.57 - $280.99
Q3 2020	435,575	$118,523	$275.88	$253.97 - $306.08
Q2 2020	431,950	$125,387	$271.12	$222.39 - $299.21
Q1 2020	396,850	$94,412	$229.39	$197.47 - $249.85
Q4 2019	374,425	$81,981	$202.38	$165.23 - $225.66
Q3 2019	372,573	$63,120	$176.91	$165.27 - $188.44
Q2 2019	371,517	$68,126	$174.82	$163.68 - $191.71
Q1 2019	365,512	$67,233	$184.70	$160.95 - $195.81
Q4 2018	325,085	$53,860	$173.27	$151.80 - $194.92
Q3 2018	313,237	$60,364	$178.07	$164.70 - $193.78
Q2 2018	321,346	$54,569	$155.01	$144.07 - $172.00
Q1 2018	321,146	$52,340	$163.34	$146.21 - $178.15
Q4 2017	312,506	$46,835	$148.07	$136.50 - $158.04
Q3 2017	296,881	$45,134	$150.51	$125.50 - $167.86
Q2 2017	282,815	$36,445	$120.38	$107.24 - $137.26
Q1 2017	272,933	$29,842	$88.04	$73.34 - $111.88
Q4 2016	267,437	$19,703	$81.37	$71.46 - $97.93
Q3 2016	258,913	$22,577	$94.50	$83.50 - $103.73
Q2 2016	249,017	$21,419	$86.41	$75.92 - $96.49
Q1 2016	248,207	$19,728	$90.45	$75.90 - $124.96
Q4 2015	239,624	$30,153	$120.72	$101.49 - $134.71
Q3 2015	225,605	$23,489	$128.47	$97.45 - $143.45
Q2 2015	225,718	$27,871	$125.98	$113.68 - $137.50
Q1 2015	231,374	$27,300	$119.81	$103.75 - $136.33
Q4 2014	230,257	$27,356	$112.63	$96.43 - $124.35
Q3 2014	227,938	$25,604	$95.21	$84.41 - $116.88
Q2 2014	225,775	$21,373	$70.12	$59.79 - $98.80
Q1 2014	226,298	$16,005	$79.20	$67.49 - $87.77
Q4 2013	223,643	$16,616	$69.64	$58.06 - $78.38
Q3 2013	207,369	$15,722	$79.58	$73.43 - $89.96
Q2 2013	146,688	$11,718	$73.64	$51.28 - $87.47