VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY's Holding History (CIK: 0000714142)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 40,323 Value ($000) $18 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 42,581 Value ($000) $17 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 68,180 Value ($000) $30 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 62,995 Value ($000) $31 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 63,057 Value ($000) $25 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 96,836 Value ($000) $45 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 98,645 Value ($000) $46 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 103,727 Value ($000) $43 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 116,512 Value ($000) $47 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 143,748 Value ($000) $50 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 153,427 Value ($000) $54 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 154,687 Value ($000) $49 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 149,187 Value ($000) $43 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 149,248 Value ($000) $43,214 Avg Close $287.72 Range $271.61 - $305.95

Q1 2022

Shares 261,130 Value ($000) $68,147 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 180,267 Value ($000) $39,587 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 181,612 Value ($000) $32,942 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 119,512 Value ($000) $24,097 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 114,512 Value ($000) $24,607 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 129,010 Value ($000) $30,490 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 136,727 Value ($000) $37,206 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 132,827 Value ($000) $38,561 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 89,696 Value ($000) $21,343 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 105,546 Value ($000) $23,109 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 123,746 Value ($000) $20,965 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 118,546 Value ($000) $21,739 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 115,796 Value ($000) $21,301 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 114,046 Value ($000) $18,898 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 111,346 Value ($000) $21,461 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 121,846 Value ($000) $20,709 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 115,346 Value ($000) $18,799 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 111,396 Value ($000) $16,694 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 108,318 Value ($000) $16,468 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 95,518 Value ($000) $12,310 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 103,718 Value ($000) $11,342 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 114,150 Value ($000) $8,409 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 116,350 Value ($000) $10,147 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 128,450 Value ($000) $11,050 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 114,750 Value ($000) $9,121 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 33,000 Value ($000) $4,152 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 33,000 Value ($000) $3,437 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 33,000 Value ($000) $4,075 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 71,356 Value ($000) $8,418 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 83,580 Value ($000) $9,930 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 92,230 Value ($000) $10,358 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 37,700 Value ($000) $3,569 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 67,837 Value ($000) $4,797 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 85,221 Value ($000) $6,332 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 94,551 Value ($000) $7,168 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 138,459 Value ($000) $11,085 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	40,323	$18	$431.03	$392.50 - $464.44
Q3 2025	42,581	$17	$417.92	$362.50 - $484.56
Q2 2025	68,180	$30	$460.83	$416.60 - $510.77
Q1 2025	62,995	$31	$466.00	$397.25 - $519.68
Q4 2024	63,057	$25	$463.53	$377.85 - $519.88
Q3 2024	96,836	$45	$480.37	$456.07 - $510.64
Q2 2024	98,645	$46	$434.05	$391.01 - $486.43
Q1 2024	103,727	$43	$422.74	$403.43 - $448.40
Q4 2023	116,512	$47	$369.42	$341.85 - $413.00
Q3 2023	143,748	$50	$349.73	$335.82 - $367.00
Q2 2023	153,427	$54	$336.94	$313.47 - $354.94
Q1 2023	154,687	$49	$299.93	$282.21 - $325.19
Q4 2022	149,187	$43	$304.77	$283.58 - $324.75
Q3 2022	149,248	$43,214	$287.72	$271.61 - $305.95
Q1 2022	261,130	$68,147	$237.33	$214.66 - $263.58
Q4 2021	180,267	$39,587	$194.45	$176.36 - $224.49
Q3 2021	181,612	$32,942	$195.24	$180.02 - $204.88
Q2 2021	119,512	$24,097	$209.17	$185.33 - $222.78
Q1 2021	114,512	$24,607	$219.65	$204.62 - $242.99
Q4 2020	129,010	$30,490	$229.44	$202.57 - $280.99
Q3 2020	136,727	$37,206	$275.88	$253.97 - $306.08
Q2 2020	132,827	$38,561	$271.12	$222.39 - $299.21
Q1 2020	89,696	$21,343	$229.39	$197.47 - $249.85
Q4 2019	105,546	$23,109	$202.38	$165.23 - $225.66
Q3 2019	123,746	$20,965	$176.91	$165.27 - $188.44
Q2 2019	118,546	$21,739	$174.82	$163.68 - $191.71
Q1 2019	115,796	$21,301	$184.70	$160.95 - $195.81
Q4 2018	114,046	$18,898	$173.27	$151.80 - $194.92
Q3 2018	111,346	$21,461	$178.07	$164.70 - $193.78
Q2 2018	121,846	$20,709	$155.01	$144.07 - $172.00
Q1 2018	115,346	$18,799	$163.34	$146.21 - $178.15
Q4 2017	111,396	$16,694	$148.07	$136.50 - $158.04
Q3 2017	108,318	$16,468	$150.51	$125.50 - $167.86
Q2 2017	95,518	$12,310	$120.38	$107.24 - $137.26
Q1 2017	103,718	$11,342	$88.04	$73.34 - $111.88
Q4 2016	114,150	$8,409	$81.37	$71.46 - $97.93
Q3 2016	116,350	$10,147	$94.50	$83.50 - $103.73
Q2 2016	128,450	$11,050	$86.41	$75.92 - $96.49
Q1 2016	114,750	$9,121	$90.45	$75.90 - $124.96
Q4 2015	33,000	$4,152	$120.72	$101.49 - $134.71
Q3 2015	33,000	$3,437	$128.47	$97.45 - $143.45
Q2 2015	33,000	$4,075	$125.98	$113.68 - $137.50
Q1 2015	71,356	$8,418	$119.81	$103.75 - $136.33
Q4 2014	83,580	$9,930	$112.63	$96.43 - $124.35
Q3 2014	92,230	$10,358	$95.21	$84.41 - $116.88
Q2 2014	37,700	$3,569	$70.12	$59.79 - $98.80
Q1 2014	67,837	$4,797	$79.20	$67.49 - $87.77
Q4 2013	85,221	$6,332	$69.64	$58.06 - $78.38
Q3 2013	94,551	$7,168	$79.58	$73.43 - $89.96
Q2 2013	138,459	$11,085	$73.64	$51.28 - $87.47