VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

AMERICAN CENTURY COMPANIES INC's Holding History (CIK: 0000748054)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 848,639 Value ($000) $384,739 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 449,193 Value ($000) $175,922 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 538,132 Value ($000) $239,576 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 465,741 Value ($000) $225,801 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 473,360 Value ($000) $190,622 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 484,813 Value ($000) $225,477 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 586,322 Value ($000) $274,821 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 694,894 Value ($000) $290,473 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 800,537 Value ($000) $325,731 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 944,868 Value ($000) $328,568 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 1,001,430 Value ($000) $352,413 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,150,902 Value ($000) $362,285 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 1,131,015 Value ($000) $326,615 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 1,260,097 Value ($000) $364,849 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 1,179,534 Value ($000) $332,381 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1,100,875 Value ($000) $287,295 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 624,453 Value ($000) $137,130 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 769,506 Value ($000) $139,581 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 900,260 Value ($000) $181,520 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 717,185 Value ($000) $154,116 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 931,832 Value ($000) $220,230 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 1,028,168 Value ($000) $279,785 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 813,313 Value ($000) $236,113 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,099,241 Value ($000) $261,565 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,125,864 Value ($000) $246,508 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 989,877 Value ($000) $167,705 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 921,176 Value ($000) $168,925 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 910,109 Value ($000) $167,415 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 959,557 Value ($000) $159,008 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,148,425 Value ($000) $221,347 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,125,428 Value ($000) $191,278 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 246,017 Value ($000) $40,096 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 178,106 Value ($000) $26,691 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 163,546 Value ($000) $24,866 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 224,353 Value ($000) $28,912 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 160,499 Value ($000) $17,551 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 289,974 Value ($000) $21,362 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 732,603 Value ($000) $63,890 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 1,317,854 Value ($000) $113,362 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,756,022 Value ($000) $139,586 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 1,510,545 Value ($000) $190,072 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 1,210,088 Value ($000) $126,019 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 627,236 Value ($000) $77,451 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 668,176 Value ($000) $78,825 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 117,542 Value ($000) $13,964 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 117,495 Value ($000) $13,196 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 147,400 Value ($000) $13,956 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 169,000 Value ($000) $11,952 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 202,186 Value ($000) $15,022 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 381,360 Value ($000) $28,915 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 325,172 Value ($000) $25,971 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	848,639	$384,739	$431.03	$392.50 - $464.44
Q3 2025	449,193	$175,922	$417.92	$362.50 - $484.56
Q2 2025	538,132	$239,576	$460.83	$416.60 - $510.77
Q1 2025	465,741	$225,801	$466.00	$397.25 - $519.68
Q4 2024	473,360	$190,622	$463.53	$377.85 - $519.88
Q3 2024	484,813	$225,477	$480.37	$456.07 - $510.64
Q2 2024	586,322	$274,821	$434.05	$391.01 - $486.43
Q1 2024	694,894	$290,473	$422.74	$403.43 - $448.40
Q4 2023	800,537	$325,731	$369.42	$341.85 - $413.00
Q3 2023	944,868	$328,568	$349.73	$335.82 - $367.00
Q2 2023	1,001,430	$352,413	$336.94	$313.47 - $354.94
Q1 2023	1,150,902	$362,285	$299.93	$282.21 - $325.19
Q4 2022	1,131,015	$326,615	$304.77	$283.58 - $324.75
Q3 2022	1,260,097	$364,849	$287.72	$271.61 - $305.95
Q2 2022	1,179,534	$332,381	$267.66	$233.01 - $293.17
Q1 2022	1,100,875	$287,295	$237.33	$214.66 - $263.58
Q4 2021	624,453	$137,130	$194.45	$176.36 - $224.49
Q3 2021	769,506	$139,581	$195.24	$180.02 - $204.88
Q2 2021	900,260	$181,520	$209.17	$185.33 - $222.78
Q1 2021	717,185	$154,116	$219.65	$204.62 - $242.99
Q4 2020	931,832	$220,230	$229.44	$202.57 - $280.99
Q3 2020	1,028,168	$279,785	$275.88	$253.97 - $306.08
Q2 2020	813,313	$236,113	$271.12	$222.39 - $299.21
Q1 2020	1,099,241	$261,565	$229.39	$197.47 - $249.85
Q4 2019	1,125,864	$246,508	$202.38	$165.23 - $225.66
Q3 2019	989,877	$167,705	$176.91	$165.27 - $188.44
Q2 2019	921,176	$168,925	$174.82	$163.68 - $191.71
Q1 2019	910,109	$167,415	$184.70	$160.95 - $195.81
Q4 2018	959,557	$159,008	$173.27	$151.80 - $194.92
Q3 2018	1,148,425	$221,347	$178.07	$164.70 - $193.78
Q2 2018	1,125,428	$191,278	$155.01	$144.07 - $172.00
Q1 2018	246,017	$40,096	$163.34	$146.21 - $178.15
Q4 2017	178,106	$26,691	$148.07	$136.50 - $158.04
Q3 2017	163,546	$24,866	$150.51	$125.50 - $167.86
Q2 2017	224,353	$28,912	$120.38	$107.24 - $137.26
Q1 2017	160,499	$17,551	$88.04	$73.34 - $111.88
Q4 2016	289,974	$21,362	$81.37	$71.46 - $97.93
Q3 2016	732,603	$63,890	$94.50	$83.50 - $103.73
Q2 2016	1,317,854	$113,362	$86.41	$75.92 - $96.49
Q1 2016	1,756,022	$139,586	$90.45	$75.90 - $124.96
Q4 2015	1,510,545	$190,072	$120.72	$101.49 - $134.71
Q3 2015	1,210,088	$126,019	$128.47	$97.45 - $143.45
Q2 2015	627,236	$77,451	$125.98	$113.68 - $137.50
Q1 2015	668,176	$78,825	$119.81	$103.75 - $136.33
Q4 2014	117,542	$13,964	$112.63	$96.43 - $124.35
Q3 2014	117,495	$13,196	$95.21	$84.41 - $116.88
Q2 2014	147,400	$13,956	$70.12	$59.79 - $98.80
Q1 2014	169,000	$11,952	$79.20	$67.49 - $87.77
Q4 2013	202,186	$15,022	$69.64	$58.06 - $78.38
Q3 2013	381,360	$28,915	$79.58	$73.43 - $89.96
Q2 2013	325,172	$25,971	$73.64	$51.28 - $87.47