VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ROYAL LONDON ASSET MANAGEMENT LTD's Holding History (CIK: 0000863748)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 273,433 Value ($000) $123,964 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 277,196 Value ($000) $108,561 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 283,345 Value ($000) $126,145 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 335,642 Value ($000) $162,726 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 363,278 Value ($000) $146,292 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 363,130 Value ($000) $168,885 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 369,750 Value ($000) $173,309 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 416,246 Value ($000) $173,995 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 387,803 Value ($000) $157,793 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 390,508 Value ($000) $135,823 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 311,507 Value ($000) $109,594 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 255,273 Value ($000) $80,429 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 90,877 Value ($000) $26,235 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 86,482 Value ($000) $25,040 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 90,423 Value ($000) $25,492 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 89,765 Value ($000) $23,426 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 86,787 Value ($000) $19,061 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 90,792 Value ($000) $16,472 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 94,307 Value ($000) $19,018 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 99,526 Value ($000) $21,395 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 96,377 Value ($000) $22,767 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 99,043 Value ($000) $26,777 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 99,059 Value ($000) $28,250 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 102,824 Value ($000) $23,841 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 102,824 Value ($000) $22,523 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 103,757 Value ($000) $17,577 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 98,653 Value ($000) $18,090 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 104,809 Value ($000) $19,276 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 107,001 Value ($000) $17,272 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 102,731 Value ($000) $19,801 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 105,089 Value ($000) $17,866 Avg Close $155.01 Range $144.07 - $172.00

Q2 2016

Shares 82,359 Value ($000) $7,083 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 4,703,700 Value ($000) $59 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 86,989 Value ($000) $10,995 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 87,160 Value ($000) $9,077 Avg Close $128.47 Range $97.45 - $143.45

Q4 2014

Shares 75,390 Value ($000) $89,827 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 57,872 Value ($000) $6,592 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 54,772 Value ($000) $4,755 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 54,979 Value ($000) $3,724 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 53,816 Value ($000) $4,209 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 53,387 Value ($000) $4,106 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 52,188 Value ($000) $4,202 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	273,433	$123,964	$431.03	$392.50 - $464.44
Q3 2025	277,196	$108,561	$417.92	$362.50 - $484.56
Q2 2025	283,345	$126,145	$460.83	$416.60 - $510.77
Q1 2025	335,642	$162,726	$466.00	$397.25 - $519.68
Q4 2024	363,278	$146,292	$463.53	$377.85 - $519.88
Q3 2024	363,130	$168,885	$480.37	$456.07 - $510.64
Q2 2024	369,750	$173,309	$434.05	$391.01 - $486.43
Q1 2024	416,246	$173,995	$422.74	$403.43 - $448.40
Q4 2023	387,803	$157,793	$369.42	$341.85 - $413.00
Q3 2023	390,508	$135,823	$349.73	$335.82 - $367.00
Q2 2023	311,507	$109,594	$336.94	$313.47 - $354.94
Q1 2023	255,273	$80,429	$299.93	$282.21 - $325.19
Q4 2022	90,877	$26,235	$304.77	$283.58 - $324.75
Q3 2022	86,482	$25,040	$287.72	$271.61 - $305.95
Q2 2022	90,423	$25,492	$267.66	$233.01 - $293.17
Q1 2022	89,765	$23,426	$237.33	$214.66 - $263.58
Q4 2021	86,787	$19,061	$194.45	$176.36 - $224.49
Q3 2021	90,792	$16,472	$195.24	$180.02 - $204.88
Q2 2021	94,307	$19,018	$209.17	$185.33 - $222.78
Q1 2021	99,526	$21,395	$219.65	$204.62 - $242.99
Q4 2020	96,377	$22,767	$229.44	$202.57 - $280.99
Q3 2020	99,043	$26,777	$275.88	$253.97 - $306.08
Q2 2020	99,059	$28,250	$271.12	$222.39 - $299.21
Q1 2020	102,824	$23,841	$229.39	$197.47 - $249.85
Q4 2019	102,824	$22,523	$202.38	$165.23 - $225.66
Q3 2019	103,757	$17,577	$176.91	$165.27 - $188.44
Q2 2019	98,653	$18,090	$174.82	$163.68 - $191.71
Q1 2019	104,809	$19,276	$184.70	$160.95 - $195.81
Q4 2018	107,001	$17,272	$173.27	$151.80 - $194.92
Q3 2018	102,731	$19,801	$178.07	$164.70 - $193.78
Q2 2018	105,089	$17,866	$155.01	$144.07 - $172.00
Q2 2016	82,359	$7,083	$86.41	$75.92 - $96.49
Q1 2016	4,703,700	$59	$90.45	$75.90 - $124.96
Q4 2015	86,989	$10,995	$120.72	$101.49 - $134.71
Q3 2015	87,160	$9,077	$128.47	$97.45 - $143.45
Q4 2014	75,390	$89,827	$112.63	$96.43 - $124.35
Q3 2014	57,872	$6,592	$95.21	$84.41 - $116.88
Q2 2014	54,772	$4,755	$70.12	$59.79 - $98.80
Q1 2014	54,979	$3,724	$79.20	$67.49 - $87.77
Q4 2013	53,816	$4,209	$69.64	$58.06 - $78.38
Q3 2013	53,387	$4,106	$79.58	$73.43 - $89.96
Q2 2013	52,188	$4,202	$73.64	$51.28 - $87.47