VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

VAN ECK ASSOCIATES CORP's Holding History (CIK: 0000869178)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 149,451 Value ($000) $68 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 149,056 Value ($000) $58 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 140,701 Value ($000) $63 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 141,691 Value ($000) $69 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 159,269 Value ($000) $64 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 151,428 Value ($000) $71 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 144,840 Value ($000) $68 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 151,898 Value ($000) $63 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 174,227 Value ($000) $71 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 153,761 Value ($000) $53 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 164,129 Value ($000) $58 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 175,664 Value ($000) $55 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 163,663 Value ($000) $47 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 175,170 Value ($000) $50,718 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 160,931 Value ($000) $45,348 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 144,730 Value ($000) $37,770 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 159,522 Value ($000) $35,031 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 179,178 Value ($000) $32,501 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 141,293 Value ($000) $28,489 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 120,890 Value ($000) $25,978 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 112,074 Value ($000) $26,488 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 100,137 Value ($000) $27,249 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 105,577 Value ($000) $30,650 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 74,744 Value ($000) $17,785 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 90,070 Value ($000) $19,721 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 104,083 Value ($000) $17,634 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 110,811 Value ($000) $20,321 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 116,428 Value ($000) $21,417 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 115,254 Value ($000) $19,099 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 129,302 Value ($000) $24,922 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 139,904 Value ($000) $23,778 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 133,105 Value ($000) $21,693 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 189,944 Value ($000) $28,465 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 207,332 Value ($000) $31,523 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 232,145 Value ($000) $29,917 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 336,864 Value ($000) $36,836 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 340,586 Value ($000) $25,091 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 281,836 Value ($000) $24,579 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 256,402 Value ($000) $22,056 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 270,805 Value ($000) $21,526 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 251,954 Value ($000) $31,703 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 251,151 Value ($000) $26,155 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 282,777 Value ($000) $34,917 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 281,462 Value ($000) $33,204 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 246,683 Value ($000) $29,306 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 258,671 Value ($000) $29,051 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 301,319 Value ($000) $28,529 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 360,636 Value ($000) $25,504 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 313,353 Value ($000) $23,282 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 242,435 Value ($000) $18,381 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 179,806 Value ($000) $14,395 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	149,451	$68	$431.03	$392.50 - $464.44
Q3 2025	149,056	$58	$417.92	$362.50 - $484.56
Q2 2025	140,701	$63	$460.83	$416.60 - $510.77
Q1 2025	141,691	$69	$466.00	$397.25 - $519.68
Q4 2024	159,269	$64	$463.53	$377.85 - $519.88
Q3 2024	151,428	$71	$480.37	$456.07 - $510.64
Q2 2024	144,840	$68	$434.05	$391.01 - $486.43
Q1 2024	151,898	$63	$422.74	$403.43 - $448.40
Q4 2023	174,227	$71	$369.42	$341.85 - $413.00
Q3 2023	153,761	$53	$349.73	$335.82 - $367.00
Q2 2023	164,129	$58	$336.94	$313.47 - $354.94
Q1 2023	175,664	$55	$299.93	$282.21 - $325.19
Q4 2022	163,663	$47	$304.77	$283.58 - $324.75
Q3 2022	175,170	$50,718	$287.72	$271.61 - $305.95
Q2 2022	160,931	$45,348	$267.66	$233.01 - $293.17
Q1 2022	144,730	$37,770	$237.33	$214.66 - $263.58
Q4 2021	159,522	$35,031	$194.45	$176.36 - $224.49
Q3 2021	179,178	$32,501	$195.24	$180.02 - $204.88
Q2 2021	141,293	$28,489	$209.17	$185.33 - $222.78
Q1 2021	120,890	$25,978	$219.65	$204.62 - $242.99
Q4 2020	112,074	$26,488	$229.44	$202.57 - $280.99
Q3 2020	100,137	$27,249	$275.88	$253.97 - $306.08
Q2 2020	105,577	$30,650	$271.12	$222.39 - $299.21
Q1 2020	74,744	$17,785	$229.39	$197.47 - $249.85
Q4 2019	90,070	$19,721	$202.38	$165.23 - $225.66
Q3 2019	104,083	$17,634	$176.91	$165.27 - $188.44
Q2 2019	110,811	$20,321	$174.82	$163.68 - $191.71
Q1 2019	116,428	$21,417	$184.70	$160.95 - $195.81
Q4 2018	115,254	$19,099	$173.27	$151.80 - $194.92
Q3 2018	129,302	$24,922	$178.07	$164.70 - $193.78
Q2 2018	139,904	$23,778	$155.01	$144.07 - $172.00
Q1 2018	133,105	$21,693	$163.34	$146.21 - $178.15
Q4 2017	189,944	$28,465	$148.07	$136.50 - $158.04
Q3 2017	207,332	$31,523	$150.51	$125.50 - $167.86
Q2 2017	232,145	$29,917	$120.38	$107.24 - $137.26
Q1 2017	336,864	$36,836	$88.04	$73.34 - $111.88
Q4 2016	340,586	$25,091	$81.37	$71.46 - $97.93
Q3 2016	281,836	$24,579	$94.50	$83.50 - $103.73
Q2 2016	256,402	$22,056	$86.41	$75.92 - $96.49
Q1 2016	270,805	$21,526	$90.45	$75.90 - $124.96
Q4 2015	251,954	$31,703	$120.72	$101.49 - $134.71
Q3 2015	251,151	$26,155	$128.47	$97.45 - $143.45
Q2 2015	282,777	$34,917	$125.98	$113.68 - $137.50
Q1 2015	281,462	$33,204	$119.81	$103.75 - $136.33
Q4 2014	246,683	$29,306	$112.63	$96.43 - $124.35
Q3 2014	258,671	$29,051	$95.21	$84.41 - $116.88
Q2 2014	301,319	$28,529	$70.12	$59.79 - $98.80
Q1 2014	360,636	$25,504	$79.20	$67.49 - $87.77
Q4 2013	313,353	$23,282	$69.64	$58.06 - $78.38
Q3 2013	242,435	$18,381	$79.58	$73.43 - $89.96
Q2 2013	179,806	$14,395	$73.64	$51.28 - $87.47