VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

HSBC HOLDINGS PLC's Holding History (CIK: 0000873630)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 630,289 Value ($000) $285,886 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 637,332 Value ($000) $249,455 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 641,961 Value ($000) $285,727 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 844,675 Value ($000) $408,562 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 873,755 Value ($000) $351,726 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 855,016 Value ($000) $397,442 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 904,742 Value ($000) $425,144 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 805,942 Value ($000) $336,840 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 614,669 Value ($000) $250,232 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 560,807 Value ($000) $195,123 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 682,193 Value ($000) $239,944 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 563,315 Value ($000) $177,387 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 488,590 Value ($000) $140,766 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 311,868 Value ($000) $90,907 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 330,760 Value ($000) $93,178 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 348,228 Value ($000) $90,503 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 379,213 Value ($000) $83,575 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 401,059 Value ($000) $72,880 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 358,145 Value ($000) $71,648 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 301,467 Value ($000) $64,652 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 359,735 Value ($000) $84,130 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 298,664 Value ($000) $81,335 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 224,066 Value ($000) $65,046 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 227,049 Value ($000) $53,486 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 210,339 Value ($000) $47,001 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 274,379 Value ($000) $46,485 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 251,763 Value ($000) $46,168 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 157,914 Value ($000) $29,049 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 144,990 Value ($000) $23,809 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 211,853 Value ($000) $40,824 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 194,081 Value ($000) $32,985 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 281,001 Value ($000) $45,798 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 251,951 Value ($000) $37,757 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 313,427 Value ($000) $47,652 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 255,759 Value ($000) $32,961 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 145,351 Value ($000) $15,901 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 127,284 Value ($000) $9,377 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 108,608 Value ($000) $9,471 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 104,320 Value ($000) $8,974 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 124,768 Value ($000) $9,918 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 115,880 Value ($000) $14,582 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 163,528 Value ($000) $17,030 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 460,751 Value ($000) $56,875 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 270,830 Value ($000) $31,998 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 248,031 Value ($000) $29,471 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 298,486 Value ($000) $33,556 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 198,150 Value ($000) $18,725 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 182,591 Value ($000) $12,797 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 149,698 Value ($000) $11,107 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 119,951 Value ($000) $9,097 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 5,645 Value ($000) $451 Avg Close $73.64 Range $51.28 - $87.47

Q1 2013

Shares 24,194 Value ($000) $1,330 Avg Close $48.01 Range $42.72 - $55.93

Q4 2012

Shares 413 Value ($000) $17 Avg Close — Range —

Q3 2012

Shares 48,644 Value ($000) $2,722 Avg Close — Range —

Q2 2012

Shares 28,821 Value ($000) $1,612 Avg Close — Range —

Q1 2012

Shares 382,200 Value ($000) $15,674 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	630,289	$285,886	$431.03	$392.50 - $464.44
Q3 2025	637,332	$249,455	$417.92	$362.50 - $484.56
Q2 2025	641,961	$285,727	$460.83	$416.60 - $510.77
Q1 2025	844,675	$408,562	$466.00	$397.25 - $519.68
Q4 2024	873,755	$351,726	$463.53	$377.85 - $519.88
Q3 2024	855,016	$397,442	$480.37	$456.07 - $510.64
Q2 2024	904,742	$425,144	$434.05	$391.01 - $486.43
Q1 2024	805,942	$336,840	$422.74	$403.43 - $448.40
Q4 2023	614,669	$250,232	$369.42	$341.85 - $413.00
Q3 2023	560,807	$195,123	$349.73	$335.82 - $367.00
Q2 2023	682,193	$239,944	$336.94	$313.47 - $354.94
Q1 2023	563,315	$177,387	$299.93	$282.21 - $325.19
Q4 2022	488,590	$140,766	$304.77	$283.58 - $324.75
Q3 2022	311,868	$90,907	$287.72	$271.61 - $305.95
Q2 2022	330,760	$93,178	$267.66	$233.01 - $293.17
Q1 2022	348,228	$90,503	$237.33	$214.66 - $263.58
Q4 2021	379,213	$83,575	$194.45	$176.36 - $224.49
Q3 2021	401,059	$72,880	$195.24	$180.02 - $204.88
Q2 2021	358,145	$71,648	$209.17	$185.33 - $222.78
Q1 2021	301,467	$64,652	$219.65	$204.62 - $242.99
Q4 2020	359,735	$84,130	$229.44	$202.57 - $280.99
Q3 2020	298,664	$81,335	$275.88	$253.97 - $306.08
Q2 2020	224,066	$65,046	$271.12	$222.39 - $299.21
Q1 2020	227,049	$53,486	$229.39	$197.47 - $249.85
Q4 2019	210,339	$47,001	$202.38	$165.23 - $225.66
Q3 2019	274,379	$46,485	$176.91	$165.27 - $188.44
Q2 2019	251,763	$46,168	$174.82	$163.68 - $191.71
Q1 2019	157,914	$29,049	$184.70	$160.95 - $195.81
Q4 2018	144,990	$23,809	$173.27	$151.80 - $194.92
Q3 2018	211,853	$40,824	$178.07	$164.70 - $193.78
Q2 2018	194,081	$32,985	$155.01	$144.07 - $172.00
Q1 2018	281,001	$45,798	$163.34	$146.21 - $178.15
Q4 2017	251,951	$37,757	$148.07	$136.50 - $158.04
Q3 2017	313,427	$47,652	$150.51	$125.50 - $167.86
Q2 2017	255,759	$32,961	$120.38	$107.24 - $137.26
Q1 2017	145,351	$15,901	$88.04	$73.34 - $111.88
Q4 2016	127,284	$9,377	$81.37	$71.46 - $97.93
Q3 2016	108,608	$9,471	$94.50	$83.50 - $103.73
Q2 2016	104,320	$8,974	$86.41	$75.92 - $96.49
Q1 2016	124,768	$9,918	$90.45	$75.90 - $124.96
Q4 2015	115,880	$14,582	$120.72	$101.49 - $134.71
Q3 2015	163,528	$17,030	$128.47	$97.45 - $143.45
Q2 2015	460,751	$56,875	$125.98	$113.68 - $137.50
Q1 2015	270,830	$31,998	$119.81	$103.75 - $136.33
Q4 2014	248,031	$29,471	$112.63	$96.43 - $124.35
Q3 2014	298,486	$33,556	$95.21	$84.41 - $116.88
Q2 2014	198,150	$18,725	$70.12	$59.79 - $98.80
Q1 2014	182,591	$12,797	$79.20	$67.49 - $87.77
Q4 2013	149,698	$11,107	$69.64	$58.06 - $78.38
Q3 2013	119,951	$9,097	$79.58	$73.43 - $89.96
Q2 2013	5,645	$451	$73.64	$51.28 - $87.47
Q1 2013	24,194	$1,330	$48.01	$42.72 - $55.93
Q4 2012	413	$17	—	—
Q3 2012	48,644	$2,722	—	—
Q2 2012	28,821	$1,612	—	—
Q1 2012	382,200	$15,674	—	—