VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CAISSE DE DEPOT ET PLACEMENT DU QUEBEC's Holding History (CIK: 0000898286)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 113,768 Value ($000) $51,578 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 222,262 Value ($000) $87,047 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 64,396 Value ($000) $28,669 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 124,847 Value ($000) $60,528 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 141,717 Value ($000) $57,069 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 371,969 Value ($000) $172,995 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 555,665 Value ($000) $260,451 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 855,109 Value ($000) $357,444 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 803,726 Value ($000) $327,028 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 816,024 Value ($000) $283,764 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 870,076 Value ($000) $306,188 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,013,223 Value ($000) $319,236 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 910,021 Value ($000) $262,796 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 1,085,220 Value ($000) $314,215 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 1,279,094 Value ($000) $360,436 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1,174,608 Value ($000) $306,537 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 1,228,508 Value ($000) $269,780 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,495,216 Value ($000) $271,217 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 57,177 Value ($000) $11,529 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 8,701 Value ($000) $1,870 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,776 Value ($000) $420 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 3,005 Value ($000) $818 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 3,605 Value ($000) $1,047 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 3,643 Value ($000) $867 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 8,405 Value ($000) $1,840 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 2,645 Value ($000) $448 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 3,305 Value ($000) $606 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 5,305 Value ($000) $976 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 5,705 Value ($000) $945 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 5,205 Value ($000) $1,003 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 5,405 Value ($000) $919 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 5,305 Value ($000) $865 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 99,905 Value ($000) $14,972 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 7,905 Value ($000) $1,207 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 7,805 Value ($000) $1,003 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 7,605 Value ($000) $833 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 7,305 Value ($000) $537 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 8,505 Value ($000) $742 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 9,005 Value ($000) $775 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 7,005 Value ($000) $557 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 104,500 Value ($000) $13,149 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 108,100 Value ($000) $11,258 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 107,100 Value ($000) $13,225 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 106,800 Value ($000) $12,599 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 116,700 Value ($000) $13,864 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 125,900 Value ($000) $14,140 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 129,200 Value ($000) $12,233 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 135,300 Value ($000) $9,568 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 131,800 Value ($000) $9,793 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 149,800 Value ($000) $11,358 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 8,200 Value ($000) $655 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	113,768	$51,578	$431.03	$392.50 - $464.44
Q3 2025	222,262	$87,047	$417.92	$362.50 - $484.56
Q2 2025	64,396	$28,669	$460.83	$416.60 - $510.77
Q1 2025	124,847	$60,528	$466.00	$397.25 - $519.68
Q4 2024	141,717	$57,069	$463.53	$377.85 - $519.88
Q3 2024	371,969	$172,995	$480.37	$456.07 - $510.64
Q2 2024	555,665	$260,451	$434.05	$391.01 - $486.43
Q1 2024	855,109	$357,444	$422.74	$403.43 - $448.40
Q4 2023	803,726	$327,028	$369.42	$341.85 - $413.00
Q3 2023	816,024	$283,764	$349.73	$335.82 - $367.00
Q2 2023	870,076	$306,188	$336.94	$313.47 - $354.94
Q1 2023	1,013,223	$319,236	$299.93	$282.21 - $325.19
Q4 2022	910,021	$262,796	$304.77	$283.58 - $324.75
Q3 2022	1,085,220	$314,215	$287.72	$271.61 - $305.95
Q2 2022	1,279,094	$360,436	$267.66	$233.01 - $293.17
Q1 2022	1,174,608	$306,537	$237.33	$214.66 - $263.58
Q4 2021	1,228,508	$269,780	$194.45	$176.36 - $224.49
Q3 2021	1,495,216	$271,217	$195.24	$180.02 - $204.88
Q2 2021	57,177	$11,529	$209.17	$185.33 - $222.78
Q1 2021	8,701	$1,870	$219.65	$204.62 - $242.99
Q4 2020	1,776	$420	$229.44	$202.57 - $280.99
Q3 2020	3,005	$818	$275.88	$253.97 - $306.08
Q2 2020	3,605	$1,047	$271.12	$222.39 - $299.21
Q1 2020	3,643	$867	$229.39	$197.47 - $249.85
Q4 2019	8,405	$1,840	$202.38	$165.23 - $225.66
Q3 2019	2,645	$448	$176.91	$165.27 - $188.44
Q2 2019	3,305	$606	$174.82	$163.68 - $191.71
Q1 2019	5,305	$976	$184.70	$160.95 - $195.81
Q4 2018	5,705	$945	$173.27	$151.80 - $194.92
Q3 2018	5,205	$1,003	$178.07	$164.70 - $193.78
Q2 2018	5,405	$919	$155.01	$144.07 - $172.00
Q1 2018	5,305	$865	$163.34	$146.21 - $178.15
Q4 2017	99,905	$14,972	$148.07	$136.50 - $158.04
Q3 2017	7,905	$1,207	$150.51	$125.50 - $167.86
Q2 2017	7,805	$1,003	$120.38	$107.24 - $137.26
Q1 2017	7,605	$833	$88.04	$73.34 - $111.88
Q4 2016	7,305	$537	$81.37	$71.46 - $97.93
Q3 2016	8,505	$742	$94.50	$83.50 - $103.73
Q2 2016	9,005	$775	$86.41	$75.92 - $96.49
Q1 2016	7,005	$557	$90.45	$75.90 - $124.96
Q4 2015	104,500	$13,149	$120.72	$101.49 - $134.71
Q3 2015	108,100	$11,258	$128.47	$97.45 - $143.45
Q2 2015	107,100	$13,225	$125.98	$113.68 - $137.50
Q1 2015	106,800	$12,599	$119.81	$103.75 - $136.33
Q4 2014	116,700	$13,864	$112.63	$96.43 - $124.35
Q3 2014	125,900	$14,140	$95.21	$84.41 - $116.88
Q2 2014	129,200	$12,233	$70.12	$59.79 - $98.80
Q1 2014	135,300	$9,568	$79.20	$67.49 - $87.77
Q4 2013	131,800	$9,793	$69.64	$58.06 - $78.38
Q3 2013	149,800	$11,358	$79.58	$73.43 - $89.96
Q2 2013	8,200	$655	$73.64	$51.28 - $87.47